Dr. Niv Papo

Dr. Niv Papo Profile

Senior lecturer
PhD, 2006

B.Sc committee - chairman

Department : Department of Biotechnology Engineering
Room : 322
בנין 41 - המכון הלאומי לביוטכנולוגיה בנגב
Phone : 972-74-7728864
972-74-7728863
972-74-7728865
972-74-7795336
972-74-7795339
972-74-7795337
Email : papo@bgu.ac.il
Office Hours :  
protein, pharmacology, protein engineering, cancer, imaging

Education

  • B.Sc. , 1997, Hebrew University of Jerusalem. Israel., Chemistry
  • M.Sc. , 2000, Hebrew University of Jerusalem. Israel., Pharmacokinetics
  • Ph.D. , 2006, Weizmann Institute of Science. Rehovot. Israel., Biological chemistry

Research Interests

  • Protein Engineering, directed evolution, ligand-receptor interactions, angiogenesis, cancer therapy, wound healing, in vivo imaging

Research Topics

  • Rational and Combinatorial Engineering of Antagonistic Angiopoietin Variants as Tools for Cancer Imaging
  • Developing bi-specific APPI peptides and small molecule conjugates that bind to both ?v?3 integrin and
  • MT1-MMP for clinical translation as diagnostic agents
    • Developing dual-specific proteins that target multiple receptors involved in angiogenesis for cancer imaging and therapy
  • Major expertise and techniques in the lab

    • Protein engineering
    • Directed evolution
    • In vivo imaging

    Publications and funding summary / representative publications and grants

    • Papo, N. , Silverman, A.P., Lahti, J.L., and Cochran, J.R. (2011) “Antagonistic VEGF Variants Engineered to Simultaneously Bind to and Inhibit VEGFR2 and ? v ? 3 Integrin”. Proc. Natl. Acad. Sci. U.S.A. 108, 14067-14072 .
    • Papo, N. , Seger , D., Makovitzki , A., Kalchenko , V., Eshhar , Z., Degani , H., and Shai,Y . (2006) “Inhibition of Tumor Growth and Elimination of Multiple Metastases in Human Prostate and Breast Xenografts by Systemic Inoculation of a Host-Defense-Like Lytic Peptide.” Cancer Res. 66, 5371-5378 . - Marie curie career integration grants (ANGIOPOIETINS) funded by the European Commission ( people programme , FP7), 100,000 €. Rational and Combinatorial Engineering of Antagonistic Angiopoietin Variants as Tools for Cancer Imaging and Therapy. - Concern Foundation , Conquer Cancer Now Award, $120,000, two years. Developing Antagonistic Protein Ligands for Cancer Imaging and Therapy .

    Existing collaborations

    • Irit Sagi: Developing bi-specific APPI peptides and small molecule conjugates that bind to both ?v?3 integrin and MT1-MMP for clinical translation as diagnostic agents
    • Eyal Mishani : Developing dual-specific proteins that target multiple receptors involved in angiogenesis for cancer imaging and therapy

    Suggested multi-disciplinary research project / research focus topics

    • Drug design
    • Protein recognition

    Looking for expertise / project

    • In vivo molecular imaging