Prof. Esther Priel

Prof. Esther Priel Profile

Professor


Department : Shraga Segal Department of Microbiology, Immunology and Genetics
School of Pharmacy
Room : 230
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם - M6
Phone : 972-8-6477257
972-8-6477254
Email : priel@bgu.ac.il
Office Hours :  
The involvement of topoisomerases and telomerase in diseases: neurodegenerative diseases, cancer, fertility disorders, diabetes

Education

  • 1973 B.Sc. - Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel. (Within the framework of Academic Reserves, Israel Defense Forces). 1976 M.Sc. - Human Genetics, Sackler School of Medicine, Tel-Aviv University. (Supervisor: Prof. Nechama S. Kosower). Thesis: "Glucose-6- phosphate Dehydrogenase Deficiency in E.coli behavior under normal and stress conditions" 1980 D.Sc. - Molecular Biology, Technion Institute of Technology, Haifa. (Supervisor: Prof. Ruth Ben-Ishai. Thesis: "Research on constitutive and inducible postreplication repair mechanisms in E.coli and the role of DNA gyrase in this process".

Research Topics

  • Topoisomerases in cancer and cancer stem cells: Regulation and drug development.
  • Topoisomerases in infectious diseases: effect on regulation of gene expression
  • The role of Topoisomerases expression and activity in the brain IV. Telomerase in the brain:
  • The expression and the role of telomerase in various brain regions and in DNA repair pathways.
  • The effect of novel telomerase activators on the onset and progression of neurodegenerative diseases.
  • Adult human stem cells: the effect of telomerase activators on the survival and viability of human mesenchymal stem cells derived from ALS, MS and healthy donors.
  • Topoisomerase and telomerase in diabetes type I: Role in gene expression and protective effect of telomerase activators from diabetes induced complications.
  • Telomerase and topoisomerase in fertility 

Publications and funding summary / representative publications and grants

  • Zehorai E, Eitan E, Hershfinkel M, Sekler I, Priel E. (2008) Glutamate regulates the activity of topoisomerase I in mouse cerebellum. Mol. Neurobiol . 38(3): 242-252 2.
  • Tichon A, Gowda BK, Slavin S, Gazit A, Priel E .(2009) Telomerase activity and expression in adult human mesenchymal stem cells derived from Amyotrophic Lateral Sclerosis individuals. Cytotherapy 11:837-848 3.
  •      Eitan E., Tichon A., Gitler D., Priel E., ( 2011) Telomerase Expression in Adult

         and Old Mouse Purkinje Neurons. Rejuvination Res.  15(2):206-209

  •             Eitan E., Tichon A., Gazit A., Gitler D., Slavin S., Priel E.  (2012) Novel

        telomerase increasing compound in mouse brain delays the onset of

        Amyotrophic Lateral Sclerosis. EMBO Mol Med 4(4): 313-329     

         activity and GlcNAcylation in rat organs: kidney liver and pancreas.

         Glycobiology 22(5): 704-713  

  • Tichon A, Eitan E, Kurkalli BG, Braiman A, Gazit A, Slavin S, Beith-Yannai E.

         Priel E.  (2013) Oxidative stress protection by novel telomerase activators in

         mesenchymal stem cells derived from healthy and diseased individuals. Curr.

         Mol. Medicine 13(6) 1010-1022.

  •                     Afriat, R., Horowitz, S., Priel, E. (2013) Mycoplasma fermentans inhibits the

          activity of the cellular DNA topoisomerase I by activation of PARP1 and

          altered the efficacy of its anti-cancer inhibitor. PLoS One 8(8):e72377. doi: 10.1371

      

  •     Liani-Leibson, K., Har-Vardi, I., Priel, E. (2014) Inhibition of topoisomerase I

          by anti cancer drug altered the endometrial cyclicity and receptivity. Curr.

          Mol. Medicine    14(1): 141-150 . 

  •          Peleg, R. Bobilev, D. Priel, E. (2014) Topoisomerase I as a target of erlotinib and gefitinib:Efficacy of combined treatments with camptothecin. Int. J. Oncology . 44(3) 934-942. 
  •            Laster B.H., Isaacson C., Perets E., Msamra M., Priel E., Kalef-Ezra J., Kost J. (2014) Keeping Those Telomeres Short! An Innovative Intratumoral Long-term Drug Delivery System. Journal of cancer research and clinical oncology (In Press DOI 10.1007/s00432-014-1747-7)
  • Grin Y, Admoni T, Priel E. (2014)Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay J Vis Exp. (JoVE) Sep 2;(91):e51865. doi: 10.3791/51865 
  •  Peleg R, Romzova M, Kogan-ZviaginI, Apte RN, Priel E (2014) Modificationof topoisomerases in mammospheres derived from breast cancer cell line: clinical implications for combined treatments with tyrosine kinase inhibitors. BMC Cancer. 3;14(1):910. [Epub ahead of print]
  •  Eitan E, Braverman C, Tichon A, Gitler D, Hutchison ER, Mattson MP, Priel E. Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons. 2016 Cerebellum. 2015 Sep 15. [Epub ahead of print]PMID:26374457

12.  Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparii M, Rokkas CK, Santos JH, Priel E, Gutterman DD. 2016.  Critical Role for Telomerase in the Mechanism of Flow Mediated Dilation in the Human Microcirculation  Circ Res. 2015 Dec 23. pii: CIRCRESAHA.115.307918. [Epub ahead of print] PMID:26699654

13.  Erez Eitan, Ailon Tichon, Esther Priel.  2016 Dissociation between telomerase activity and expression during mice cortical development due to a DNA-bound telomerase inhibitor. Matters Select. https://science matters.io/articles/201604000008

Existing collaborations

  • Yael Segev - Topoisomerase and telomerase in type I diabetes
  • Yafa Mizrachi Nebenzahl- The effect of S.pneumoniae infection on the cellular topoisomerase I 3. Daniel Gitler- The expression and the role of topoisomerase in the brain
  • Alex Breiman- hMSC and telomerase increasing compounds
  • David Stepansky- Methods for identifying the AGS-telomerase increasing compounds in cells, tissue and serum.
  • Etta Livneh- Cancer stem cells from breast and prostate tumors: topoisomerases and PKC etta.
  • Iris Har-Vardi: male and female fertility