Prof. Israel Sekler

Prof. Israel Sekler Profile

Ph.D. 1992

Department : Physiology and Cell Biology
Room : 428
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם - M6
Phone : 972-8-6477330
Email :
Office Hours :  
imaging, membrane protein, cell imaging, protein


  • B.Sc. 1981-1984 The Hebrew University of Jerusalem, Faculty of Agriculture, Department of Animal Physiology. M.Sc. 1984-1986 Weizmann Institute of Science, Department of Chemical Immunology, supervised by Prof. Zvi Fishelzon. "Identification of the Regulatory Site of the Complement Protein Factor-H". Ph.D. 1987-1992 Weizmann Institute of Science, Department of Biochemistry, supervised by Prof. Uri Pick. "Structure Function and Regulation of The Plasma Membrane Proton Pump From the Acidophylic Alga- Dunaliella-Acidophila".

Research Topics

  • Zinc role in neuronal diseases
  • Zinc homeonstatic proteins
  • Molecular identity of mitochondrial Ca2+ shuttling proteins
  • Mitochondrial role in neurological processses and hormone secretion

Major expertise and techniques in the lab

  • Cellular and tissue imaging
  • Structure functional analysis of membrane protein

Publications and funding summary / representative publications and grants

  • Palty R, Silverman WF, Hershfinkel M, Caporale T, Sensi SL, Parnis J, Nolte, C, Fishman D, Shoshan-Barmatz V, Hermann D, Khananshvili D, Sekler I. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange, PNAS 107: 436-441.
  • Grants: ISF and BSF

Existing collaborations

  • Michal Hershfinkel - Zinc homeostasis and signaling
  • Eli Lewis - Role of mitochondrial signaling in insulin secretion
  • Dimitri Fishman and Michael Danilenko - Mitochondrial signaling and cancer

Suggested multi-disciplinary research project / research focus topics

  • Zinc and health
  • Mitochondria in health and disease