Prof. Amnon Sintov
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Associate Professor
Department :
Department of Biomedical Engineering
Room :
302
בנין כימיה וטכנולוגיה כימית, 3
Phone :
972-8-6461939
972-8-6461976
972-8-6472700
972-8-6461953
972-8-6472709
Email :
asintov@bgu.ac.il
Office Hours :
Education
The Hebrew University of Jerusalem, Jerusalem, Israel. B.Sc. in Biochemistry - Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel; M.Sc. in Chemistry of Polymers and Textiles - School of Applied Science, Faculty of Sciences, The Hebrew University of Jerusalem, Israel. M.Sc. dissertation thesis: Controlled Release of Biphenyl from Polypropylene Fibers; Ph.D. - School of Pharmacy, The Hebrew University of Jerusalem, Israel. Ph.D dissertation thesis: Pharmacokinetics of T-2 Toxin in Dogs. Isolation and Structure Determination of the Metabolites Produced in the Dogs during In-Vivo Metabolism of T-2 Toxin; Post-Doctoral Fellow - Pediatric Cardiology Research Labs., University of Michigan Medical Center, and the College of Pharmacy, The University of Michigan, Ann Arbor, Michigan. Research Topics: 1. Antiarrhythmic drug delivery systems, 2. Antiparkinsonian controlled release implants, 3. Pharmacokinetics of epicardial administration, and Synthesis of non-calcifiable polymers for artificial heart.
Research Interests
General:
Pharmaceutics and biopharmaceutics, Topical, Transdermal and Transmucosal Drug Delivery
Specific:
Formulation factors controlling drug deposition into the skin upon topical application; maximization of drug bioavailability and efficacy, minimization of toxicity, and improvement of patient compliance. Experimental systems utilized in the lab have been selected to evaluate the percutaneous permeation of various dermal drug products. These systems include in-vitro techniques employing excised animal skin mounted on diffusion cells, as well as in vivo procedures and PK/PD studies. The group has been involved in electrically-assisted diffusion of drugs into the skin (e.g., iontophoresis), in skin penetration of drugs via micro-fabricated microneedles, and in preparation of microemulsion systems and some new penetration enhancers to facilitate percutaneous and transmucosal penetration. The activities have also included mechanistic studies of transdermal delivery of proteins having disulfide bond, i.e., the mechanism by which dermal reducing agents inactivate the protein molecule and inhibit its pharmacological action upon dermal application. In addition, The group is involved in the area of generic drugs, in development of topical formulations and test their in-vitro bioequivalence.
Overall Research Scope: The central theme of Prof. Sintov’s research details formulation factors controlling drug deposition into the skin upon topical application Research Activities: Prof. Sintov’s general research is focused on topical, transdermal and intramucosal drug delivery. Experimental systems utilized in his lab have been selected to evaluate the percutaneous permeation of various topical drug products. These systems include in-vitro techniques employing excised animal skin mounted on diffusion cells, as well as in vivo procedures and PK/PD studies. Prof. Sintov’s laboratory is also involved in the targeting of drugs into the hair follicle (pilosebaceous unit), which allows delivery of topical drugs in follicle-associated diseases such as cystic acne, androgenetic alopecia, fungal infections, and some forms of cancerous tumors.