Associate Professor
Ph.D. 2007
pathogen, protein complexes, transmembrane domains, secretion systems |
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- 10/1998-07/2000 Hebrew University, Jerusalem, Israel, Faculty of Life Sciences. AMIRIM TEVA program for excellence. B. Sc. degree, November 2000, with high honors “Magna Cum Laude”.
- 10/2000-06/2007 Feinberg Graduate School of the Weizmann Institute of Science, Biological Chemistry Department, Rehovot, Israel. Direct Ph.D track, Completion date: May, 2007. Thesis topic: Protein-Protein Interactions within the Membrane environment. Supervisor: Prof. Shai Yechiel.
- Host-pathogen Interactions, bacterial pathogenesis, macromolecular complexes, trasport systems.
- Transport systems in bacterial pathogens
- Host membrane targeting by enteric pathogens
- Trans-membrane domains within the bacterial transport systems
Publications and funding summary / representative publications and grants
- Peer-reviewed articles :
- 1. Sal-Man N ., Setiaputra D., Scholz R., Deng W., Yu ACY., Strynadka NCJ., and Finlay BB. (2013) “ EscE and EscG are co-chaperones for the type III needle protein EscF of enteropathogenic E. coli. ” J. Bacteriol. 195 (11), 2481-2489.
- 2. Sal-Man N ., Biemans-Oldehinkel E., Sharon D., Croxen MA., Scholz R., Foster LJ., and Finlay BB. (2012) “ EscA is a crucial component of the type III secretion system of enteropathogenic E. coli .” J. Bacteriol . 194 (11), 2819-2828.
- 3. Fink A., Sal-Man N ., Gerber D., and Shai Y. (2012) “Transmembrane Domains Interactions within the Membrane Milieu: Principles, Advances and Challenges.” Biochim Biophys Acta. 1818(4), 974-983.
- 4. Sal-Man N ., Wanyin D., and Finlay BB. (2012) “EscI – A Crucial Component of the Type III Secretion System Forms the Inner Rod Structure in Enteropathogenic Escherichia coli .“ Biochem. J . 442, 119–125.
- 5. Biemans-Oldehinkel E.*, Sal-Man N .*, Deng W., Foster LJ., and Finlay BB. (2011) “ Quantitative Proteomic Analysis Reveals Formation of an EscL-EscQ-EscN Type III Complex in Enteropathogenic Escherichia coli . ” J. Bacteriol ., 193, 5514-5519.
- * Authors equally contributed to this work.
- 6. Sal-Man N. , Croxen MA., Finlay BB. (2011) “ Translocation of effectors: revisiting the injectosome model. ” Future Microbiol . 6, 483-484.
- 7. Sal-Man N ., Biemans-Oldehinkel E ., and Finlay BB . (2009) “Structural microengineers: pathogenic Escherichia coli redesigns the actin cytoskeleton in host cells.” Structure , 17, 15-19.
- 8. Sal-Man N. , Gerber D., Bloch I., and Shai Y. (2007) "Specificity in Transmembrane Helix-Helix Interaction Mediated by Aromatic Residues." J. Biol. Chem. 282, 19753-19761.
- 9. Kristian SA., Timmer AM., Liu GY., Lauth X., Sal-Man N ., Rosenfeld, Y., Shai Y., Gallo RL., and Nizet V. (2006) “Impairment of innate immue killing mechanisms by bacteriostatic antibiotics.” FASEB J. 21, 1107-1116.
- 10. Sal-Man N. , Gerber D., and Shai Y. (2005) “The identification of a minimal dimerization motif QXXS that enables homo- and hetero-association of transmembrane helices in vivo.” J. Biol. Chem. 280, 27449-27557.
- 11. Sal-Man N. , and Shai Y. (2005) “Arginine Mutations within a Transmembrane Domain Can Drive Homodimer Dissociation and Heterodimer Association In Vivo .” Biochem. J. 385, 29-36.
- 12. Sal-Man N. , Gerber D., and Shai Y. (2004) “Hetero-assembly between all-L- and all-D-amino acid transmembrane domains: forces involved and implication for inactivation of membrane proteins.” J. Mol. Biol., 344, 855-864.
- 13. Gerber D., Sal-Man N ., and Shai Y. (2004) “Structural Adaptation of the Glycophorin A Transmembrane Homodimer.” J. Mol. Biol., 339, 243-250.
- 14. Gerber D., Sal-Man N ., and Shai Y. (2004) “Two motifs within a Transmembrane Domain - One for Homodimerization and the Other for Heterodimerization.” J. Biol . Chem ., 279, 21177-21182.
- 15. Sal-Man N. , Gerber D., Shai Y. (2004) "Composition Rather Than Position of Polar Residues (QxxS) Drives Aspartate Receptor Transmembrane Domain Dimerization in Vivo ." Biochemistry , 43, 2309-2313.
- 16. Schwarz M., Sal-Man N. , Zamir A. and Pick U. (2003) "A Transferrin-like Protein that Does Not Bind Iron is Induced by Iron Deficiency in the Alga Dunaliella salina." Biochim Biophys Acta. , 1649, 190-200.
- 17. Sal-Man N. , Oren Z., Shai Y. (2002) "Preassembly of Membrane-Active Peptides is an Important Factor in their Selectivity toward Target Cells." Biochemistry , 41, 11921-11930.
- 18. Rotem D., Sal-Man N. , Schuldiner S. (2001) "In vitro Monomer Swapping in EmrE, A Multidrug Transporter from Escherichia coli, Reveals that the Oligomer is the Functional Unit." J. Biol. Chem. 276, 48243-48249.