Dr. Leslie Lobel

Dr. Leslie Lobel Profile

Senior lecturer
M.D., Ph.D.,1988

Department : Shraga Segal Department of Microbiology, Immunology and Genetics
School of Pharmacy
Center for Emerging Diseases, Tropical Diseases and AIDS (CEMTA)
Room : 324
M2 - בי"ח סורוקה (בנין פתולוגיה)
Phone : 972-8-6479841
972-8-6479941
972-8-6479944
Email : llobel@bgu.ac.il
Office Hours :  
virology, immunology, serology, ebola, antibodies

Education

  • M.D., Ph.D. 1988Columbia College, Columbia University; College of Physicians and Surgeons, Columbia University.

Research Interests

  • Replication competent retroviral vector
  • filamentous phage display libraries
  • immunoprospecting and human monoclonal antibodies
  • lymphoma specific monoclonal immunoglobulins
  • immunoglobulin profiling,
  • combinatorial biology

Research Topics

  • Isolation of human m onoclonal a ntibodies for viral therapy and prophylaxis and development of virus anti- virus therapies.
  • Identification of predictors of effective humoral immunity in viral disease
  • Humoral immune profiling in viral disease for diagnostics and prognostics
  • Africa: Comprehensive viral surveillance strategies
  • Africa: Ebolavirus Sudan Gulu
  • identification of the effective humoral immune response and therapeutics development

Major expertise and techniques in the lab

  • Human monoclonal antibody isolation and production
  • Viral reverse genetic systems
  • Development of novel serological techniques
  • Advanced cell culture systems

Publications and funding summary / representative publications and grants

  • Ariel Sobarzo , Allison Groseth , Olga Dolnik , Stephan Becker, Julius Julian Lutwama , Eddie Perelman, Victoria Yavelsky, Majidat Muhammad, John M. Dye, Robert S. Marks, and Leslie Lobel (2012). Profile and persistence of the virus-specific neutralizing humoral immune response in human survivors of Sudan ebolavirus Gulu . (Submitted JID)
  • A . Sobarzo A, J. T. Paweska , S. Herrmann , T. Amir , R. S. Marks and L. Lobel (2007) Optical fiber immunosensor for the detection of IgG antibody to Rift Valley fever virus in humans. Journal of Virological Methods Dec;146(1-2):327-34 .
  • Natalie Gavrilov-Yisum , Ekaterina Hahiashvili , Marina Tashker , Ohad Karnielli and Leslie Lobel (2008) In vitro enhancement of cell division, hybridoma formation and clonability in Nanoparticle-Doped Water. BMC Biotechnology Jan 14;8(1):3.
  • Rudchenko S, Scanlan M, Kalantarov G, Yavelsky V, Levy C, Estabrook A, Old L, Chan G, Lobel L and Trakht
  • (2008) A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen. BMC Cancer 8: 248. 5. Yavelsky V, Rohkin S, Shako-Levi R, Tzikinovsky A, Amir T, Kohn H, Delgado B, Rabinovich A, Piura B, Chan G, Trakht I and Lobel L. (2008) Native Human Autoantibodies Targeting GIPC1 Identify Differential Expression in Malignant Tumors of the Breast and Ovary. BMC Cancer 8: 247 . Active Funding : Kamin , DTRA-USDA, NIBN
  • Existing collaborations

    • Robert Marks– Development of advanced serological assays for viral hemorrhagic fever.
    • Zvi Bentiwich – Factors affecting humoral immunity in Africa.
    • Shosh Arad/Mahmoud Hulihel - Studies of Algal extracts on influenza virus replication.
    • Eli Lewis-Persistence of Cell mediated immunity in survivors of ebolavirus hemorrhagic fever.
    • Raz Jelinek -Virus membrane interactions.

    Suggested multi-disciplinary research project / research focus topics

    • Host virus interactions in immunity to disease
    • Predictors of effective viral immunity
    • Development of a advanced computer technologies for viral surveillance

    Looking for expertise / project

    • Serology and viral isolation and diagnostics.
    • Epidemiology and computer science
    • High throughput sequencing.