||And in the diabetic patients in the HOT Study, an achieved
difference of systolic blood pressure of 4 mmHg was associated with a halving in the
number of cardiovascular events. A finding of complete reversibility of risk would suggest
that, whatever the mechanisms whereby vascular stiffness increases risk, it is the levels
of pressure in the stiffened vessel which are responsible for the thrombotic risk in that
vessel. Yet greater than full reversibility must suggest other mechanisms of benefit, and
these remain to be explored.