zinc homeostasis, mediated by zinc sensing receptors and transporters.
My research group is particularly interested in:
1) zinc brain homeostasis, as this ion has an important role during normal activity, yet it is highly toxic to neuronal cells.
2) Mechanisms linking zinc to cell growth and proliferation with particular emphasis on the role of zinc in wound healing.
Key words describing my research would be:
Zinc homeostasis, zinc sensing receptor, zinc signaling in the brain, zinc transport, zinc in wound healing.
1. To find the most efficacious vaccination regime based on these 8 proteins, by altering the number of immunizations, site of immunization or adjuvant type in the mouse intranasal inoculation model system.
2. To identify protein fragments from the selected proteins that retain their protective immunogenicity in the mouse challenge model, but which do not display any linear sequence homology to human proteins.
3. To screen for the presence of antibodies against these fragments in the sera of infants and young Jewish and Bedouin populations in Israel.
4. To optimize the protective immunity by examining and comparing immunity conferred by different combinations of fragments and to explore the possibility of ligating the fragments to form a single polypeptide chain.
5. To prepare human vaccine-quality proteins (GMP).
6. Pre-IND application to the FDA.
the differences between immune responses in S. pneumoniae carriage and in S. pneumoniae disease are as yet unclear. To understand better how an appropriate protective immune response is developed will require insight into the relative contribution of innate and adaptive immune responses, and characterization of S. pneumoniae virulence factors plus their cognate host receptors. Such advances are critical to the development of future therapeutic or preventive interventions.