Golan Laboratory

 

 

Hava Golan, Ph.D

 

 

Senior Lecturer

Developmental Molecular Genetics

Faculty of Health Sciences

&

Zlotowski Center for Brain research

Ben-Gurion University, Beer-Sheva, Israel

 

Epigenetic and Environmental Factors in

Embryonic Brain Development:

1.    Epigenetic effects of MTHFR polymorphism

on brain development

Tel: Office: 972-8-647-9974

Laboratory: 972-8-647-9961/2

2. Prenatal Hypoxia

Mail: havag@bgu.ac.il

3. Antiepileptic Drugs

Students:

Ph.D students:

Levav Tamar

Tendeitnik Pini

 

M.Sc Students:

Melamed Osnat

Elinor Blumkin

Molczadzki Gabriela

Chava Atlas-Zukerman

 

Noa Golan

 

 

 

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Publications:

 

             1.     Ben-Yaakov G. and Golan H. 2003. Cell proliferation in response to GABA in postnatal hippocampal slice culture. Int. J. of Developmental Neurosci. 21(3): 153-157.

             2.     Golan H., Levav T., Mendelsohn A. and Huleihel M. 2004. Involvement of tumor necrosis factor alpha in hippocampal development and function. Cerebral Cortex, 14:97-105.

             3.     Golan H., Levav T., Huleihel M. 2004. Distinct expression and distribution of vesicular proteins in the hippocampus of TNFa-deficient mice during development. Synapse. 53:6-10.

             4.     Levav T., Saar T., Berkovitch L., Golan H. 2004. Perinatal exposure to GABA-transaminase inhibitor impaired psychomotor function in the developing and adult mouse. International J. of Developmental Neuroscience. 22(3):137-147.

             5.     Huleihel M., Golan H. and Hallak M. 2004. Systemic maternal infection/inflammation during pregnancy and offspring brain damages. Reproductive Biology and Endocrinology. 2(1):17-22.

             6.     Golan H., Kashtutsky I., Hallak M., Sorokin Y. and Huleihel M. 2004. Maternal hypoxia during pregnancy delayed the development of motor reflex in newborn mice. Developmental Neuroscience. 26(1): 24 - 29.

             7.     Golan H., Kashtutsky I., Hallak M., and Huleihel M. 2004. Maternal hypoxia during pregnancy induces fetal neurodevelopmental brain damage; protection by magnesium sulfate. J. of Neuroscience Research. 78(3):430-441

             8.     Golan H., Lev V., Hallak M., Sorokin Y. and Huleihel M. 2005. Specific neurodevelopmental damage in offspring following maternal inflammation during pregnancy. Neuropharmacology. 48(6):903-917.

             9.     Gerstein M. Huleihel M., Mane R., Stilman M., Kashtuzki I, Hallak M., Golan H. 2005. Remodeling of hippocampal GABAergic system in adult offspring after maternal hypoxia and magnesium sulfate load: immuno-histo- chemical study. Experimental Neurology. 196:18-29.

         10.     Golan H., Huleihel M. 2005. Prenatal hypoxia effect on brain development short and long term consequences. Review in the Special Issue of Developmental Science. Hypoxia: An Acute, Chronic and Intermittent Challenge to Cognitive Development

         11.     Golan H, Lev, V, Mazar Y, Hallak M. Sorokin Y. and Huleihel M. 2006. Alterations in behavior in adult offspring following maternal inflammation during pregnancy. Developmental Psychobiology. 48(2): 162-168.

         12.     Golan H., Stilman M., Lev V., and Huleihel M. 2006. Normal aging of offspring mice of mothers with induced inflammation during pregnancy. Neuroscience 141:1909-1918.

         13.     Louzoun-Kaplan V., Zuckerman M., Perez-Polo JR and Golan, HM. 2008. Prenatal hypoxia down regulates the GABA pathway in newborn mice cerebral cortex; partial protection by MgSO4. International J. of Developmental Neuroscience. 26:77-85.

         14.     Levav T., Wirthaim O, Grossman Y, Golan HM. 2008. Impaired synaptogenesis and long-term modulation of behavior following neonatal elevation of GABA levels in mice. Neuropharmacology. 54:387-398.

         15.     Bazak N, Kozlovsky N, Kaplan Z, Matar M, Golan H, Zohar J, Richter-Levin G, Cohen H. 2009. Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor. Psychoneuroendocrinology. 34(6):844-58.

         16.     Golan HM, Mane R, Molczadzki G, Zuckerman M, Kaplan- Louson V, Huleihel M, Perez-Polo J. R. 2009. Impaired migration signaling in the hippocampus following prenatal hypoxia. Neuropharmacology. 57: 511-522.

         17.     Haramati O, Mane R, Molczadzki G, Perez-Polo JR, Chalifa-Caspi V, Golan MH. 2009. Magnesium sulfate treatment alters fetal cerebellar gene expression responses to hypoxia. International J. of Developmental Neuroscience 28(2):207-216.

         18.     Levav-Rabkin T, Melamed O, Farber M, Grossman Y, Clarke G, Cryan JF., Dinan TG., Golan HM. 2010. A sensitive period of the inhibitory system to neonatal GABA enhancement in mice. Neuropsychopharmacology. 35(5):1138-1154.

         19.     Levav-Rabkin T, Blumkin E, Galron D, Golan HM. Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice. Behav Brain Res. 2011 Jan 20;216(2):505-13.

         20.     Blumkin E, Levav-Rabkin T, Melamed O., Galron D, Golan HM. Gender-specific effect of MTHFR genotype and neonatal vigabatrin interaction on synaptic proteins in mouse cortex. Neuropsychopharmacology, 2011 36(8):1714-28.

 

 

 

 

 

 

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