{"id":2,"date":"2013-01-10T11:17:27","date_gmt":"2013-01-10T11:17:27","guid":{"rendered":"http:\/\/localhost\/wordpress\/?page_id=2"},"modified":"2025-04-02T13:25:11","modified_gmt":"2025-04-02T10:25:11","slug":"israelson-lab-page","status":"publish","type":"page","link":"https:\/\/fohs.bgu.ac.il\/israelsonlab\/","title":{"rendered":""},"content":{"rendered":"<h2 style=\"text-align: center;\"><strong><span style=\"color: #000000;\">Welcome to <span style=\"color: #333333;\">the Israelson lab for Cellular and Molecular Neurodegeneration<\/span>!<\/span><\/strong><\/h2>\n<div style=\"width: 604px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-2-1\" width=\"604\" height=\"403\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/02\/Israelson-lab.mp4?_=1\" \/><a href=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/02\/Israelson-lab.mp4\">https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/02\/Israelson-lab.mp4<\/a><\/video><\/div>\n<h2><\/h2>\n<h2 style=\"text-align: justify;\">Our research<\/h2>\n<p><a href=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/?attachment_id=667\" rel=\"attachment wp-att-667\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-667 size-medium\" src=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/11\/WhatsApp-Image-2020-10-22-at-18.12.33-300x225.jpeg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/11\/WhatsApp-Image-2020-10-22-at-18.12.33-300x225.jpeg 300w, https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/11\/WhatsApp-Image-2020-10-22-at-18.12.33-768x576.jpeg 768w, https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/11\/WhatsApp-Image-2020-10-22-at-18.12.33-1024x768.jpeg 1024w, https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/11\/WhatsApp-Image-2020-10-22-at-18.12.33-1200x900.jpeg 1200w, https:\/\/fohs.bgu.ac.il\/israelsonlab\/wp-content\/uploads\/2020\/11\/WhatsApp-Image-2020-10-22-at-18.12.33.jpeg 1600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">The main focus of the research in our lab is on the cellular and molecular mechanisms that lead to the onset and progression of neurodegenerative diseases (e.g., Alzheimer&#8217;s disease, Parkinson&#8217;s disease, Huntington&#8217;s disease) with special emphasis on amyotrophic lateral sclerosis (ALS, Lou Gehrig&#8217;s disease). These devastating diseases represent a major challenge to public health worldwide, especially as our population continues to age.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">ALS is a progressive adult-onset neurodegenerative disorder characterized by the selective loss of upper and lower motor neurons in the brain and spinal cord, followed by paralysis and ultimately death within 2-5 years. The typical age of onset is between 50 to 60 years for most forms of ALS. The disease significantly affects the patient&#8217;s quality of life, being characterized by progressive muscle weakness, atrophy and spasticity. Today, the disease is incurable, and there is no effective treatment to cure or even significantly slow disease progression.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">We combine biochemistry, molecular biology and use both cellular and in vivo models to investigate the molecular mechanisms involved in ALS pathogenesis.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Our long term aim is to identify new candidate agents that will be able to slow or stop the progression of the disease. These agents will be tested in pre-clinical studies and will be the basis to develop new drugs for the treatment of ALS and other neurodegenerative disorders.<\/span><\/p>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"<p>Welcome to the Israelson lab for Cellular and Molecular Neurodegeneration! Our research The main focus of the research in our lab is on the cellular and molecular mechanisms that lead to the onset and progression of neurodegenerative diseases (e.g., Alzheimer&#8217;s disease, Parkinson&#8217;s disease, Huntington&#8217;s disease) with special emphasis on amyotrophic lateral sclerosis (ALS, Lou Gehrig&#8217;s &hellip; <a href=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\"><\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>- Israelson lab<\/title>\r\n<meta name=\"description\" content=\"The main focus of the research in our lab is on the cellular and molecular mechanisms that lead to the onset and progression of neurodegenerative diseases (e.g., Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease) with special emphasis on amyotrophic lateral sclerosis (ALS, Lou Gehrig\u2019s disease). 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