{"id":77,"date":"2013-04-20T18:49:55","date_gmt":"2013-04-20T18:49:55","guid":{"rendered":"http:\/\/localhost\/wordpress\/?page_id=77"},"modified":"2026-01-20T16:17:44","modified_gmt":"2026-01-20T13:17:44","slug":"research","status":"publish","type":"page","link":"https:\/\/fohs.bgu.ac.il\/israelsonlab\/?page_id=77","title":{"rendered":"Research"},"content":{"rendered":"

Our current efforts are focused on understanding the following molecular and cellular mechanisms:<\/p>\n

    \n
  1. Characterization of macrophage migration inhibitory factor (MIF) as a potential therapeutic target for ALS (Israelson et al, 2015 Neuron<\/strong><\/em>; Leyton et al, 2016 PNAS<\/strong><\/em>; Shvil et al, 2018 Cell Death & Dis<\/strong><\/em>; Alaskarov et al, 2022 Sci. Rep., <\/strong><\/em>Alfahel et al, 2024 Cell Rep.Med<\/strong><\/em>)<\/li>\n
  2. Approaches to gene modulation therapy for ALS (Leyton et al, 2019 PNAS, <\/strong><\/em>Alfahel et al, 2024 Cell Rep.Med<\/strong><\/em>)<\/li>\n
  3. Nucleocytoplasmic transport dysfunction in SOD1 ALS (Argueti-Ostrovsky et al, 2026 Mol. Neurodegen.<\/strong><\/em>)<\/li>\n
  4. Mitochondrial dysfunction in ALS pathogenesis (Israelson et al, 2010 Neuron<\/strong><\/em>; Li et al, 2010 PNAS<\/strong><\/em>; Shteinfer et al, 2019 Front. Cell Neurosci; <\/strong><\/em>Shteinfer et al, 2022 Int. J. Mol. Sci.<\/strong><\/em>)<\/li>\n
  5. The effect of T lymphocytes in ALS pathogenesis (Zaccai et al, 2024 J. Neuroinflammation<\/strong><\/em>)<\/li>\n
  6. Characterization of new antibodies for misfolded SOD1 (Bakavayev et al, 2021 ACS Chem. Neurosci.; <\/strong><\/em>Bakavayev et al, 2023 Brain<\/strong><\/em>)<\/li>\n
  7. Characterization of new molecular chaperones for misfolded SOD1 (Getter et al, 2015 ChemMedChem<\/strong><\/em>.; Alfahel et al, 2022 Int. J. Mol. Sci.;\u00a0<\/strong><\/em>Ribeiro et al, 2023 Biol. Chem.<\/strong><\/em>)<\/li>\n
  8. Characterization of different empty and loaded nanoparticles and nanovesicles as a possible therapeutic strategy for ALS and other neurodegenerative diseases (Leyton et al, 2020 Sci. Rep.<\/strong><\/em>)<\/li>\n<\/ol>\n

    \n","protected":false},"excerpt":{"rendered":"

    Our current efforts are focused on understanding the following molecular and cellular mechanisms: Characterization of macrophage migration inhibitory factor (MIF) as a potential therapeutic target for ALS (Israelson et al, 2015 Neuron; Leyton et al, 2016 PNAS; Shvil et al, 2018 Cell Death & Dis; Alaskarov et al, 2022 Sci. Rep., Alfahel et al, 2024 … Continue reading Research<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-77","page","type-page","status-publish","hentry"],"yoast_head":"\r\nResearch - Israelson lab<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/?page_id=77\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Research - Israelson lab\" \/>\r\n<meta property=\"og:description\" content=\"Our current efforts are focused on understanding the following molecular and cellular mechanisms: Characterization of macrophage migration inhibitory factor (MIF) as a potential therapeutic target for ALS (Israelson et al, 2015 Neuron; Leyton et al, 2016 PNAS; Shvil et al, 2018 Cell Death & Dis; Alaskarov et al, 2022 Sci. 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