{"id":86,"date":"2013-04-20T18:57:27","date_gmt":"2013-04-20T18:57:27","guid":{"rendered":"http:\/\/localhost\/wordpress\/?page_id=86"},"modified":"2026-02-22T12:28:51","modified_gmt":"2026-02-22T09:28:51","slug":"publications","status":"publish","type":"page","link":"https:\/\/fohs.bgu.ac.il\/israelsonlab\/?page_id=86","title":{"rendered":"Selected Publications"},"content":{"rendered":"

To our full list of publications from PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=israelson+a&sort=date<\/a><\/p>\n

Argueti-Ostrovsky S*, Lim SM*, Arogundade OA, Diaz-Garcia S, Yunisova G, Meng A, Hermann A, Ong K, Eremenko E, Bravo-Hernandez M, Driscoll SP, Lee C-Z, Jiang X, Stavsky A, Barel S, Shani T, Kahn J, Pfaff SL, Monsonego A, Marsala M, Ravits J, Lagier-Tourenne C# and Israelson A#<\/strong>. Impaired Nucleocytoplasmic Transport inSOD1-Mediated ALS. Mol. Neurodegeneration<\/em><\/strong><\/a> 21, 14 (2026) .<\/p>\n

Ionescu A*, Ankol L*, Subramaniam AG,Altman T, Magen I, Cohen Y,\u00a0Danino Y, Geller D, Ibraheem A, Cheng R, Gradus-Pery T, Alfahel L, Duc P, Ergul-Ulger Z, Arslan D,Tan E, Rage F, Riva N, Quattrini A, Bekircan-Kurt CE, Israelson A<\/strong>, Dori A, Hornstein E\u00a0<\/sup>and Perlson E. Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models. Nature Neuroscience<\/strong><\/em><\/a> 28, 2201-2216 (2025).<\/p>\n

Alfahel L*, Gschwendtberger T*, Kozareva V, Dumas L, Gibbs R, Kertser A, Baruch K, Zaccai S, Kahn J, Thau-Habermann N, Eggenschwiler R, Sterneckert J, Herrmann A, Rafuse V, Fraenkel E, Cantz T, Petri S and Israelson A<\/strong>. Targeting low levels of MIF expression as a potential therapeutic strategy for ALS. Cell Rep. Med<\/a>.<\/em><\/strong> 5, 101546 (2024).<\/p>\n

Zaccai S, Nemirovski A, Lerner L, Alfahel L, Eremenko E, Israelson A#<\/strong>, Monsonego A#. CD4 T-Cell Aging Exacerbates Neuroinflammation in a Late-Onset Mouse Model of Amyotrophic Lateral Sclerosis. J. Neuroinflammation<\/em><\/strong><\/a> 21, 17 (2024). (#corresponding author)<\/p>\n

Bakavayev S, Stavsky A, Argueti-Ostrovsky S, Yehezkel G, Barak Z, Gitler D, \u00a0Israelson A#<\/strong>, and Engel S#. Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis. Brain <\/em><\/strong><\/a>146, 4594-4607 (2023). (#corresponding author)<\/p>\n

Shteinfer-Kuzmine A*, Argueti-Ostrovsky S*, Leyton-Jaimes M, Anand U, Abu-Hamad S, Zalk R, Shoshan-Barmatz V# and Israelson A#<\/strong>. Targeting the mitochondrial protein VDAC1 as a potential therapeutic strategy in ALS. Int. J. Mol. Sci<\/em><\/strong><\/a> 23, 9946 (2022).<\/p>\n

Alfahel L*, Argueti-Ostrovsky S*, Barel S*, Ali Saleh M, Kahn J, Azoulay-Ginsburg S, Rothstein A, Ebbinghaus S, Gruzman A and Israelson A<\/strong>. 4-phenylbutyric acid (4-PBA) derivatives prevent SOD1 amyloid aggregation in vitro<\/em> with no effect on disease progression in SOD1-ALS mice. Int. J. Mol. Sci<\/em><\/strong> <\/a>23, 9403 (2022).<\/p>\n

Alaskarov A*, Barel S*, Bakavayev S, Kahn J and Israelson A<\/strong>. MIF homolog d-dopachrome tautomerase (D-DT\/MIF-2) does not inhibit accumulation and toxicity of misfolded SOD1 Sci. Rep.<\/em><\/strong><\/a> 12, 9570 (2022).<\/p>\n

Malada Edelstein Y, Solomonov Y, Hadad N, Alfahel L,\u00a0 Israelson A<\/strong> and Levy R. Early upregulation of cytosolic Phospholipase A2<\/sub>\u00ce\u00b1 in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis. J. Neuroinflammation<\/em><\/strong><\/a> 18, 274 (2021).<\/p>\n

Argueti-Ostrovsky S*, Alfahel L*, Kahn J and Israelson A.\u00a0<\/strong>All roads lead to Rome: Different molecular players converge to common toxic pathways in neurodegeneration. Cells <\/em><\/strong><\/a>10, 2438 (2021).<\/p>\n

Bakavayev S, Argueti S, Venkatachalam N, Yehezkel G, Stavsky A, Barak Z, Israelson A#<\/strong>, and Engel S#. The exposure of \u00ce\u00b26\/\u00ce\u00b27-loop in Zn\/Cu-superoxide dismutase (SOD1) is coupled to metal loss and is transiently reversible during misfolding. ACS Chem. Neurosci. <\/em><\/strong><\/a> 12, 49-62 (2021) (#corresponding author)<\/p>\n

Leyton-Jaimes M*, Ivert P*, Han Y, Hoeber J, Zhou C, Feiler A, Pankratova S, Shoshan-Barmatz V, Israelson A<\/strong>#, Kozlova E#. Empty mesoporous silica particles delay disease progression and extend survival in a mouse model of ALS. Sci. Rep.<\/em><\/strong><\/a>\u00a010, 20675 (2020) (#corresponding author)<\/p>\n

Leyton-Jaimes M, Kahn J and Israelson A<\/strong>. AAV2\/9-mediated overexpression of MIF inhibits SOD1 misfolding, delays disease onset and extends survival in mouse models of inherited ALS. Proc. Natl. Acad. Sci. USA<\/em><\/strong><\/a> 116, 14755-14760 (2019)<\/span><\/p>\n

Shteinfer-Kuzmine A*, Argueti S*, Gupta R*, Shvil N, Abu-Hamad S, Gropper Y, Hoeber J, Magri A, Messina A, Kozlova E, Shoshan-Barmatz V and Israelson A<\/strong>. A VDAC1-derived N-terminal peptide inhibits mutant SOD1-VDAC1 interactions and toxicity in the SOD1 model of ALS. Front. Cell. Neurosci.<\/em><\/strong><\/a> 13, 146 (2019)<\/span><\/p>\n

Blacher E*, <\/strong>Bashiardes S*,<\/strong> Shapiro H*,<\/strong> Rothschild D*<\/strong>, Mor U, Dori-Bachash M, Kleimeyer C, Moresi C, Harnik Y, Zur M, Zabari M, Ben-Zeev Brik R, Zmora N, Cohen Y, Bar N, Levi I, Amar N, Mehlman T, Brandis A, Biton I, Kuperman Y, Tsoory M, Shental N, Alfahel L, Harmelin A, Schwartz M, Israelson A<\/strong>, Arike L, Johansson M, Hansson G.C., Gotkine M, Segal E, Elinav E. Potential roles of gut microbiome commensals & associated metabolites 1 in modulation of murine Amyotrophic Lateral Sclerosis. Nature<\/em><\/strong><\/a> 572, 474-480 (2019)<\/span><\/p>\n

Shvil N, Banerjee V,\u00a0 Zoltsman G, Shani T, Kahn J, Abu-Hamad S, Papo N, Engel S, Bernhagen J and Israelson A<\/strong>. MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: Implications for familial ALS. Cell Death & Disease <\/em><\/strong><\/a>9,107\u00c2 (2018)\u00a0<\/span><\/p>\n

Leyton-Jaimes M, Kahn J and Israelson A.<\/strong> Macrophage Migration Inhibitory Factor: A Multifaceted Cytokine Implicated in Multiple Neurological Diseases. Exp. Neurol. <\/strong><\/em><\/a>301,83-91\u00c2 (2018)\u00a0<\/span><\/p>\n

Abu-Hamad S, Kahn J, Leyton-Jaimes M, Rosenblatt J and Israelson A<\/strong>. Misfolded SOD1 accumulation and mitochondrial association contribute to the selective vulnerability of motor neurons in familial ALS: correlation to human disease. ACS Chem. Neurosci<\/a>. <\/em><\/strong>8, 2225-2234\u00c2 (2017)<\/span><\/p>\n

Leyton-Jaimes M*, Benaim C*, Abu-Hamad S*, Guetta A, Kahn J, Bucala R, and Israelson A<\/strong>. Endogenous Macrophage Migration Inhibitory Factor Reduces the Accumulation and Toxicity of Misfolded SOD1 in a Mouse Model of ALS. Proc. Natl. Acad. Sci. USA<\/em><\/strong><\/a> 113, 10198-10203 (2016)\u00a0<\/span><\/p>\n

Israelson A<\/strong>#, Ditsworth D, Sun S, Song SW, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S and Cleveland DW#. Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1. Neuron <\/em><\/strong><\/a>86, 218-232 <\/i>(2015)\u00a0 (# corresponding author)<\/span><\/p>\n

Li Q*, Vande Velde C*, Israelson A<\/strong>, Xie J, Bailey AO, Dong M, Chun S, Roy T, Yates JR., Capaldi RA, Cleveland DW and Miller TM. ALS-linked mutant superoxide dismutase 1(SOD1) alters mitochondrial protein composition and decreases protein import. Proc. Natl. Acad. Sci. USA<\/strong><\/em><\/a>\u00a0107, 21146-21151 (2010) <\/span><\/p>\n

Israelson A<\/strong>, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V and Cleveland DW. Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron<\/strong><\/em><\/a> 67, 575-587 (2010) <\/span><\/p>\n

Google Scholar: https:\/\/scholar.google.com\/citations?user=5MgUJ90AAAAJ&hl=en<\/a><\/p>\n

PATENTS<\/span><\/strong><\/p>\n

1. <\/b>Israelson A<\/strong> and Cleveland DW. Mif for use in methods of treating subjects with a neurodegenerative disorder. Publication number: WO2013184209 A1<\/span><\/p>\n

(International Application Number PCT\/US2013\/031449) (2013).<\/span><\/p>\n

2. Shoshan-Barmatz V, Israelson A<\/strong> and Lemelson D. Fluorescent Ruthenium Compounds for Detecting Calcium Binding Proteins.<\/span><\/p>\n

(International Application Number PCT\/IL2007\/001210) (2007).<\/span><\/p>\n

3. Shoshan-Barmatz V and Israelson A<\/strong>. Photoreactive Compound Specifically Binding to Calcium Binding Proteins.<\/span><\/p>\n

(International Application Number PCT\/IL2005\/000203) (2005).<\/span><\/p>\n

4- Shoshan-Barmatz V and Israelson A<\/strong>. VDAC1-derived N-terminal peptides and use thereof for treating ALS. (International Application PCT) (2019).<\/span><\/p>\n

5- Kozlova E, Feiler A, Zhou C, Israelson A<\/strong>\u00a0and Shoshan-Barmatz V. Porous particles for use in treatment, prevention and\/or postponement of degeneration of neurons and glia. (International Application PCT) (2019).<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

To our full list of publications from PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=israelson+a&sort=date Argueti-Ostrovsky S*, Lim SM*, Arogundade OA, Diaz-Garcia S, Yunisova G, Meng A, Hermann A, Ong K, Eremenko E, Bravo-Hernandez M, Driscoll SP, Lee C-Z, Jiang X, Stavsky A, Barel S, Shani T, Kahn J, Pfaff SL, Monsonego A, Marsala M, Ravits J, Lagier-Tourenne C# and Israelson … Continue reading Selected Publications<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-86","page","type-page","status-publish","hentry"],"yoast_head":"\r\nSelected Publications - Israelson lab<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/fohs.bgu.ac.il\/israelsonlab\/?page_id=86\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Selected Publications - 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