Both the brain and the immune system begin their journey on earth with a learning process directly linked to the environmental settings to ultimately generate memory and execute effective functions; many of these functions control body homeostasis and are co-regulated throughout life. The implication of immune regulation in many disorders is thus a fast-emerging field as it holds a great promise in improving the quality of life. Studies in my laboratory focus on exploring the interactions between the brain and the immune system from early development to aging. Our ultimate goal is to provide better tools to fight autoimmune and neurodegenerative diseases, two conditions with ever-growing social and financial costs.