Publications

1. Alon Monsonego, Yael Shani, Igor Friedmann, Yoav Paas, Orly Eizenberg and Michal Schwartz. Expression of GTP-Dependent and GTP-Independent Tissue-Type TGase in Cytokine-Treated Rat Brain Astrocytes.
J Biol Chem 1997; 272(6): 3724-32.

2. Alon Monsonego, Igor Friedman Miriam Eisenstein and Michal Schwartz. GTP-dependent conformational changes associated with the functional switch between Galpha and cross-linking activities in brain-derived tissue transglutaminase.
J Mol Biol Communication 1998; 282(4): 713-720.

3. Alon Monsonego, Tal Mizrahi, Shoshana Eitan, Gila Moalem, Helga Bárdos, Róza Ádány and Michal Schwartz. Factor XIIIa as A Nerve-Associated Transglutaminase.
FASEB J. 1998; vol. 12: 1163-1171.

4. Gila Moalem, Alon Monsonego, Irun Cohen and Michal Schwartz. T Cell response to central and peripheral nerve injury: connection to immune privilege.
FASEB J. 1999;13 (10):1207-17.

5. Alon Monsonego, Ruth Maron, Victor Zota, Dennis J. Selkoe & Howard L. Weiner. Immune. Hyporesponsiveness to Amyloid beta-Peptide in APP Transgenic Mice: Implications for the Pathogenesis and Treatment of Alzheimer’s Disease.
PNAS. 2001; vol. 98; 10273-10278.

6. Alon Monsonego, Victor Zota, Arnon Karni, Jeffery I. Krieger, Amit Bar-or, Andrew Budson, Dennis Selkoe, and Howard L. Weiner.  Increased T-Cell Reactivity to Amyloid beta-Protein in Older Humans and Patients with Alzheimer’s Disease.
J. Clin. Invest. 2003 Aug 1;112(3):415-422.

7. Alon Monsonego, Jaime Imitola, Victor Zota, Takatoku Oida and Howard L. Weiner. Microglia-mediated Nitric Oxide Cytotoxicity of T Cells Following Beta-Amyloid Presentation to Th1 cells.
J. Immunol. 2003 Sep 1;171(5):2216-24.

8. Alon Monsonego, Zur P. Beserman, Jonathan Kipnis, Eti Yoles, Howard L. Weiner & Michal Schwartz.Beneficial effect of orally administered myelin basic protein in EAE susceptible Lewis rats in a model of acute CNS degeneration.
J. Autoimmun. 2003 Sep;21(2):131-8.

9. Alon Monsonego, Jaime Imitola2, Sanja Petrovic2, Victor Zota2, Anna Nemirovsky1, Rona Baron1, Yair Fisher1, Trevor Owens3, and Howard L. Weiner2. A-beta-induced meningoencephalitis is IFN-g dependent and is associated with T cell-dependent clearance of A-beta in a mouse model of Alzheimer’s disease.
PNAS, 2006 Mar 28;103(13):5048-53.

10. Basso AS, Frenkel D, Quintana FJ, Costa-Pinto FA, Petrovic-Stojkovic S, Puckett L, Monsonego A, Bar-Shir A, Engel Y, Gozin M, Weiner HL. Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis.
J Clin Invest. 2008 Apr;118(4):1532-43.

11. Baron R, Nemirovsky A, Harpaz I, Cohen H, Owens T, Monsonego A. IFN-{gamma} enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer’s disease.
FASEB J. 2008 Aug;22(8):2843-52.

12. Victor Zota, Anna Nemirovsky, Rona Baron, Yair Fisher, Dennis J. Selkoe, Daniel M. Altmann, Howard L. Weiner, and Alon Monsonego. HLA-DR alleles in amyloid beta-peptide autoimmunity: A highly immunogenic role for the DRB1*1501 allele.
J. Immunol. 2009 Sep 1;183(5):3522-30.

13. Gaikwad S., Larionov S., Matozaki T., Monsonego A., Thal D.R.  and Neumann H. Phagocytosis of amyloid-β by microglial signal regulatory protein-β1.
Am J Pathol. 2009 Dec;175(6):2528-39.

14. Tali Brunner, Smadar Cohen, and Alon Monsonego. Silencing of proinflammatory genes targeted to peritoneal-residing macrophages using siRNA encapsulated in biodegradable microspheres.
Biomaterials, 2010 Mar;31(9):2627-36.

15. Yair Fisher, Anna Nemirovsky, Rona Baron, and Alon Monsonego. T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer’s disease.
PlosOne, 2010 May 26;5(5).

16. Kaminer-Israeli Y, Shapiro J, Cohen S, Monsonego A.  Stromal cell-induced immune regulation in a transplantable lymphoid-like cell constructs.
Biomaterials. 2010 Dec;31(35):9273-84.

17. Nemirovsky A, Fisher Y, Baron R, Cohen IR, Monsonego A. Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer’s disease.
Vaccine. 2011 May 23;29(23):4043-50.

18. Yair Fisher, Anna Nemirovsky, Rona Baron and Alon Monsonego. Dendritic cells regulate Ab-specific T-cell entry into the brain: The role of perivascular Ab.
J. Alzheimer’s disease. 2011 Jul 15.

19. Nemirovsky A, Shapiro J, Baron R, Kompaniets A, Monsonego A. Active Aβ vaccination fails to enhance amyloid clearance in a mouse model of Alzheimer’s disease with Aβ42-driven pathology.
J Neuroimmunol. 2012 Jun 15;247(1-2):95-9.

20. Abutbul S, Shapiro J, Szaingurten-Solodkin I, Levy N, Carmy Y, Baron R, Jung S, Monsonego A. TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment.
Glia. 2012 Jul;60(7):1160-71.

21. Harpaz I, Abutbul S, Nemirovsky A, Gal R, Cohen H, Monsonego A. Chronic exposure to stress predisposes to higher autoimmune susceptibility in C57BL/6 mice: glucocorticoids as a double-edged sword.
Eur J Immunol. 2013 Mar;43(3):758-69.

22. Yair Fisher, Itai Strominger, Shva Biton, Anna Nemirovsky, Rona Baron and Alon Monsonego. Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance.
J Immunol. 2014 Jan 1;192(1):92-102.

23. Accelerated microglial pathology is associated with Ab plaques in mouse models of Alzheimer’s disease.
Rona Baron1, Alicia A. Babcock2, Anna Nemirovsky1, Bente Finsen2 and Alon Monsonego1 .
Aging Cell, In-press.


Selected Reviews

1. Alon Monsonego and Howard L. Weiner. Immunotherapeutic approaches in neurodegenerative diseases.
Science 2003 Oct 31; 302: 834-837.

2. Felix Mor and Alon Monsonego. Immunization Therapy in Alzheimer’s Disease.
Expert Rev. Neurotherapeutics 6  (5), 653–659 (2006).

3. Alon Monsonego, Anna Nemirovski and Idan Harpaz. CD4 T cells in immunity and immunotherapy of Alzheimer’s disease.
Immunology. 2013 Aug;139(4):438-46.