{"id":3284,"date":"2016-11-04T11:56:58","date_gmt":"2016-11-04T11:56:58","guid":{"rendered":"http:\/\/www.aivahthemes.com\/wp\/labora\/?page_id=3284"},"modified":"2026-01-03T22:14:20","modified_gmt":"2026-01-03T22:14:20","slug":"homepage","status":"publish","type":"page","link":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/","title":{"rendered":"Home page"},"content":{"rendered":"
[vc_row css=”.vc_custom_1735457543995{margin-top: 100px !important;}”][vc_column width=”1\/3″][vc_single_image image=”4193″ img_size=”full” add_caption=”yes” alignment=”center” el_id=”mainhomepics”][\/vc_column][vc_column width=”1\/3″][vc_single_image image=”4073″ img_size=”full” add_caption=”yes” alignment=”center” el_id=”mainhomepics”][\/vc_column][vc_column width=”1\/3″][vc_single_image image=”4074″ img_size=”full” add_caption=”yes” alignment=”center” el_id=”mainhomepics”][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1609101110670{margin-top: 20px !important;margin-bottom: 20px !important;}”][vc_column][vc_separator css=”.vc_custom_1609101132074{margin-top: 30px !important;margin-bottom: 45px !important;}”][\/vc_column][vc_column offset=”vc_col-lg-12 vc_col-md-12 vc_col-xs-12″ css=”.vc_custom_1610301954328{padding-right: 10px !important;padding-left: 10px !important;}”][vc_custom_heading text=”About Us” font_container=”tag:h1|font_size:42px|text_align:left” use_theme_fonts=”yes”][vc_column_text el_class=”content-area main-about”]\n
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Both the brain and the immune system begin their journey with a learning process, directly linked to the environmental settings, to ultimately generate memory and execute effector functions; many of these functions control body homeostasis and are co-regulated throughout life. The implication of immune regulation in many disorders is thus a fast-emerging field as it holds a great promise in disease prevention, early diagnosis and treatment. Studies in my laboratory focus on exploring the interactions between the brain and the immune system from early development to aging in human and in animal models. Our goal is to provide better tools to fight autoimmune, psychiatric and neurodegenerative diseases, conditions with ever-growing social and financial costs<\/span><\/p>\n<\/div>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”35″ css=”.vc_custom_1604195798057{padding-top: 40px !important;padding-bottom: 40px !important;background-color: #e4ebef !important;background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_column css=”.vc_custom_1477907239174{background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_row_inner equal_height=”yes”][vc_column_inner width=”1\/2″ offset=”vc_col-lg-6 vc_col-md-12″][vc_column_text css=”.vc_custom_1733685615773{margin-right: 50px !important;margin-left: 50px !important;}”]\n

Immune cell residence and function within the central nervous system.<\/h1>\n[\/vc_column_text][vc_separator color=”custom” align=”align_left” border_width=”3″ el_width=”10″ accent_color=”#990b6e” css=”.vc_custom_1479821931902{margin-right: 50px !important;margin-bottom: 50px !important;margin-left: 50px !important;}”][vc_column_text css=”.vc_custom_1735458875201{padding-right: 50px !important;padding-left: 50px !important;}” el_class=”content-area main-about”]Immune cells begin to populate the central nervous system (CNS) already during embryonic development. The cells, termed microglia (macrophages of the CNS), become permanent residents of the tissue with a variety of functions such as clearance of pathogens and regulation of neuronal function. We address questions related to their unique functional properties within the CNS as well as their impact on chronic diseases of the brain such as epilepsy, obesity, amyotrophic lateral sclerosis, Crohn\u2019s disease, and Alzheimer\u2019s disease.<\/span><\/p>\n

Read More at Nature.com<\/a><\/p>\n

Read More at ScienceDirect<\/a>[\/vc_column_text][vc_empty_space height=”20px”][\/vc_column_inner][vc_column_inner width=”1\/2″ css=”.vc_custom_1606940856555{background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” offset=”vc_col-lg-6 vc_col-md-12″][vc_single_image image=”4050″ img_size=”full”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”35″ css=”.vc_custom_1604195759118{padding-top: 40px !important;padding-bottom: 40px !important;background-color: #ffffff !important;background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_column css=”.vc_custom_1477907239174{background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_row_inner equal_height=”yes”][vc_column_inner width=”1\/2″ css=”.vc_custom_1606940873202{background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” offset=”vc_col-lg-6 vc_col-md-12″][vc_single_image image=”4051″ img_size=”full”][\/vc_column_inner][vc_column_inner width=”1\/2″ offset=”vc_col-lg-6 vc_col-md-12″][vc_column_text css=”.vc_custom_1733685668196{margin-right: 50px !important;margin-left: 50px !important;}”]\n

Immune mechanisms in aging, longevity, and age-related diseases<\/h1>\n[\/vc_column_text][vc_separator color=”custom” align=”align_left” border_width=”3″ el_width=”10″ accent_color=”#990b6e” css=”.vc_custom_1479821931902{margin-right: 50px !important;margin-bottom: 50px !important;margin-left: 50px !important;}”][vc_column_text css=”.vc_custom_1733685685938{padding-right: 50px !important;padding-left: 50px !important;}” el_class=”content-area main-about”]Various age-related diseases such as dementia, cancer, diabetes, and heart diseases are characterized by declined repair along with dysregulated inflammation. Our studies reveal trajectories of immune system aging which contribute to changes in the immune ecosystem and thereby manifested either as healthy aging or accumulated tissue damage and various pathologies. <\/span><\/p>\n

Read More<\/a>[\/vc_column_text][vc_empty_space height=”20px”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”35″ css=”.vc_custom_1604195808529{padding-top: 40px !important;padding-bottom: 40px !important;background-color: #e4ebef !important;background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_column css=”.vc_custom_1477907239174{background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_row_inner equal_height=”yes”][vc_column_inner width=”1\/2″ offset=”vc_col-lg-6 vc_col-md-12″][vc_column_text css=”.vc_custom_1733685704852{margin-right: 50px !important;margin-left: 50px !important;}”]\n

Mechanisms of stress-induced pathogenic autoimmunity and neuroinflammation.<\/h1>\n[\/vc_column_text][vc_separator color=”custom” align=”align_left” border_width=”3″ el_width=”10″ accent_color=”#990b6e” css=”.vc_custom_1479821931902{margin-right: 50px !important;margin-bottom: 50px !important;margin-left: 50px !important;}”][vc_column_text css=”.vc_custom_1733685724868{padding-right: 50px !important;padding-left: 50px !important;}” el_class=”content-area main-about”]Chronic stress may alter the homeostatic functioning of the gut-immune-brain axis. Such imbalance may then exacerbate or predispose to chronic illnesses such as depression, autoimmunity, and neurodegenerative diseases. Current projects<\/span> explore cellular and molecular mechanisms underlying the biology of stress-induced gut and brain pathologies. <\/span><\/p>\n

Read More<\/a>[\/vc_column_text][vc_empty_space height=”20px”][\/vc_column_inner][vc_column_inner width=”1\/2″ css=”.vc_custom_1606940919491{background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” offset=”vc_col-lg-6 vc_col-md-12″][vc_single_image image=”4274″ img_size=”full”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” gap=”35″ css=”.vc_custom_1604195844910{padding-top: 40px !important;padding-bottom: 40px !important;background-color: #ffffff !important;background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_column css=”.vc_custom_1477907239174{background-position: 0 0 !important;background-repeat: no-repeat !important;}”][vc_row_inner equal_height=”yes”][vc_column_inner width=”1\/2″ css=”.vc_custom_1606940924650{background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” offset=”vc_col-lg-6 vc_col-md-12″][vc_single_image image=”4053″ img_size=”full”][\/vc_column_inner][vc_column_inner width=”1\/2″ offset=”vc_col-lg-6 vc_col-md-12″][vc_column_text css=”.vc_custom_1733685791476{margin-right: 50px !important;margin-left: 50px !important;}”]\n

3D transplantable scaffolds for immune modulation in autoimmune diseases.<\/h1>\n[\/vc_column_text][vc_separator color=”custom” align=”align_left” border_width=”3″ el_width=”10″ accent_color=”#990b6e” css=”.vc_custom_1479821931902{margin-right: 50px !important;margin-bottom: 50px !important;margin-left: 50px !important;}”][vc_column_text css=”.vc_custom_1733685826413{padding-right: 50px !important;padding-left: 50px !important;}” el_class=”content-area main-about”]Although the etiology of autoimmune diseases is mostly unknown, it is becoming clear that a loss in immune regulation results in pathogenic stimulation of autoreactive lymphocytes which otherwise kept quiescent. Once such pathogenic stimulation of lymphocytes occurs, the cells can renew and continuously attack the body. Our research, in collaboration with Prof. Smadar Cohen, is aimed at generating transplantable lymphoid-like scaffolds which attenuate the function of pathogenic T cells and hence allow to preserve essential tissue functions.<\/span><\/p>\n

Read More<\/a>[\/vc_column_text][vc_empty_space height=”20px”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1606941268982{margin-bottom: 25px !important;}”][vc_column width=”1\/2″][vc_column_text css=”.vc_custom_1609145702045{margin-bottom: 0px !important;}”]\n

Alon Monsonego<\/span><\/h3>\n

\"\"<\/a><\/span>
\nLEARN MORE<\/a><\/span>[\/vc_column_text][vc_column_text css=”.vc_custom_1733765946169{margin-top: 15px !important;}” el_class=”content-area main-about”]Alon Monsonego, PhD
\nProfessor, Lab of Neuroimmunology
\nLawrence W. and Marie Feldman Chair in Neurophysiology
\nDeputy Vice Dean for Academic Promotion<\/p>\n

The Shraga Segal Dept. of Microbiology, Immunology and Genetics
\nThe Faculty of Health Sciences &
\nThe National Institute of Biotechnology in the Negev
\nSchool of Brain Sciences and Cognition
\nRegenerative Medicine and Stem Cell Research Center
\nBen-Gurion University
\nP.O.B. 653
\nBeer-Sheva 84105
\nIsrael<\/p>\n

Tel: +972-(0)8-647-9052<\/a>
\nFax: +972-(0)8-647-9051
\nEmail: alonmon@bgu.ac.il<\/a>
\nhttp:\/\/fohs.bgu.ac.il\/monsonegolab<\/a>[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][vc_column_text css=”.vc_custom_1767478465862{margin-top: 15px !important;}” el_class=”content-area main-about”]Selected Publications:<\/strong>\u00a0<\/span><\/p>\n