{"id":3958,"date":"2020-11-01T02:15:57","date_gmt":"2020-11-01T02:15:57","guid":{"rendered":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/?p=3958"},"modified":"2021-01-03T14:53:01","modified_gmt":"2021-01-03T14:53:01","slug":"immune-cell-residence-and-function-within-the-central-nervous-system","status":"publish","type":"post","link":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/projects\/immune-cell-residence-and-function-within-the-central-nervous-system\/","title":{"rendered":"Immune cell residence and function within the central nervous system"},"content":{"rendered":"<p><span data-contrast=\"auto\">Microglia are myeloid-derived cells that colonize the central nervous system (CNS) already at early stages of development and constitute up to 20% of the glial populations throughout life. While extensive progress has been recently made in identifying the cellular origin of microglia, the mechanism whereby the cells acquire the unique ramified and quiescent phenotype within the CNS milieu<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">and<\/span><span data-contrast=\"auto\">\u00a0the changes the cells undergo in aging and through the course of CNS disorders requires further research. For more details\u00a0<\/span><span data-contrast=\"auto\">about microglial differentiation and their role in disease\u00a0<\/span><span data-contrast=\"auto\">see the following references:\u00a0\u00a0<\/span><i><span data-contrast=\"auto\">Abutbul<\/span><\/i><i><span data-contrast=\"auto\">\u00a0et al., 2012<\/span><\/i><i><span data-contrast=\"auto\">,\u00a0<\/span><\/i><i><span data-contrast=\"auto\">Baron et al., 2014;\u00a0<\/span><\/i><i><span data-contrast=\"auto\">Andreasson<\/span><\/i><i><span data-contrast=\"auto\">\u00a0KI et al.,\u00a0<\/span><\/i><i><span data-contrast=\"auto\">2016<\/span><\/i><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><\/p>\n<div id=\"attachment_4186\" style=\"width: 394px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-content\/uploads\/2020\/11\/image-2-1.png\" rel=\"lightbox[3958]\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-4186\" class=\"wp-image-4186\" src=\"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-content\/uploads\/2020\/11\/image-2-1.png\" alt=\"Microglia processes (green) form contacts with neurons (red) in the healthy brain (Baron et al., 2014)\" width=\"384\" height=\"359\" srcset=\"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-content\/uploads\/2020\/11\/image-2-1.png 643w, https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-content\/uploads\/2020\/11\/image-2-1-300x280.png 300w\" sizes=\"auto, (max-width: 384px) 100vw, 384px\" \/><\/a><p id=\"caption-attachment-4186\" class=\"wp-caption-text\">Microglia processes (green) form contacts with neurons (red) in the healthy brain<br \/>(Baron et al., 2014)<em style=\"font-size: 16px;\">\u00a0 \u00a0\u00a0<\/em><\/p><\/div>\n<p><em>\u00a0 \u00a0 \u00a0 Our current studies are targeted to reveal the differentiation of microglia at early stages of embryogenesis using genetically-modified zebrafish (in collaboration with Dr. Niva Russek-Blum, The Dead Sea and Arava Science center).\u00a0 In addition, we study the functional properties of the cells in animal models of neurodegenerative diseases (for more details see \u201cImmune mechanisms in aging and neurodegenerative diseases\u201d).<\/em><\/p>\n<style id=\"bwg-style-0\">    #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails {      width: 1254px;              justify-content: center;        margin:0 auto !important;              background-color: rgba(255, 255, 255, 0.00);            padding-left: 4px;      padding-top: 4px;      max-width: 100%;            }        #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails .bwg-item {    justify-content: flex-start;      max-width: 250px;          }    #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails .bwg-item a {       margin-right: 4px;       margin-bottom: 4px;    }    #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails .bwg-item0 {      padding: 0px;   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<div id=\"bwg_spider_popup_loading_0\" class=\"bwg_spider_popup_loading\"><\/div>        <div id=\"spider_popup_overlay_0\" class=\"spider_popup_overlay\" onclick=\"spider_destroypopup(1000)\"><\/div>        <input type=\"hidden\" id=\"bwg_random_seed_0\" value=\"372777469\">                <\/div>    <\/div>    <script>      if (document.readyState === 'complete') {        if( typeof bwg_main_ready == 'function' ) {          if ( jQuery(\"#bwg_container1_0\").height() ) {            bwg_main_ready(jQuery(\"#bwg_container1_0\"));          }        }      } else {        document.addEventListener('DOMContentLoaded', function() {          if( typeof bwg_main_ready == 'function' ) {            if ( jQuery(\"#bwg_container1_0\").height() ) {             bwg_main_ready(jQuery(\"#bwg_container1_0\"));            }          }        });      }    <\/script>    \n","protected":false},"excerpt":{"rendered":"<p>Microglia are myeloid-derived cells that colonize the central nervous system (CNS) already at early stages of development and constitute up to 20% of the glial populations throughout life. While extensive progress has been recently made in identifying the cellular origin of microglia, the mechanism whereby the cells acquire the unique ramified and quiescent phenotype within [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4050,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-3958","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-projects"],"_links":{"self":[{"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/posts\/3958","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/comments?post=3958"}],"version-history":[{"count":18,"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/posts\/3958\/revisions"}],"predecessor-version":[{"id":4255,"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/posts\/3958\/revisions\/4255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/media\/4050"}],"wp:attachment":[{"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/media?parent=3958"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/categories?post=3958"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fohs.bgu.ac.il\/monsonegolab\/wp-json\/wp\/v2\/tags?post=3958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}