{"id":18,"date":"2024-04-17T07:42:42","date_gmt":"2024-04-17T07:42:42","guid":{"rendered":"https:\/\/fohs.bgu.ac.il\/ocohenlab\/?page_id=18"},"modified":"2026-02-22T13:22:24","modified_gmt":"2026-02-22T13:22:24","slug":"home","status":"publish","type":"page","link":"https:\/\/fohs.bgu.ac.il\/ocohenlab\/","title":{"rendered":"Ofir Cohen\u2019s lab of Computational Oncology"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_81 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\r\n<div class=\"ez-toc-title-container\">\r\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\r\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/#Tackling_evolved_drug_resistance_in_advanced_tumors\" >Tackling evolved drug resistance in advanced tumors<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/#Transcriptional_Archetypes\" >Transcriptional Archetypes<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/#Single-cell_resolution_of_clinically_interpretable_transcription_programs\" >Single-cell resolution of clinically interpretable transcription programs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/#Evolutionary_Models\" >Evolutionary Models<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/#Medical_Informatics\" >Medical Informatics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/#Digital_Pathology\" >Digital Pathology<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tackling_evolved_drug_resistance_in_advanced_tumors\"><\/span>Tackling evolved drug resistance in advanced tumors<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Our computational oncology lab spans several research directions in evolution, precision medicine, and oncology. These directions are directed toward improving patient care and providing a better understanding of the fundamental processes that govern the evolution of drug resistance in advanced malignancies.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"394\" src=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2024\/04\/Picture1.png\" alt=\"\" class=\"wp-image-89\" srcset=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2024\/04\/Picture1.png 700w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2024\/04\/Picture1-300x169.png 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-thumbnail has-custom-border is-style-rounded is-style-rounded--1\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"145\" src=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/Picture1-150x145.jpg\" alt=\"\" class=\"has-border-color has-accent-3-border-color wp-image-584\" style=\"border-width:6px;border-top-left-radius:100px;border-top-right-radius:100px;border-bottom-left-radius:100px;border-bottom-right-radius:100px\" srcset=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/Picture1-150x145.jpg 150w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/Picture1-300x290.jpg 300w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/Picture1.jpg 528w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Transcriptional_Archetypes\"><\/span><strong>Transcriptional Archetypes<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Characterization of the entire \u201clandscape\u201d of drug-resistance states by inferring the central drug-resistance \u201cArchetype\u201d as convergent evolutionary states, focusing on Metastatic Breast Cancer (MBC) and distilling commonalities across epithelial tumors.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-thumbnail has-custom-border is-style-rounded is-style-rounded--2\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/singlecell-e1771765470654-150x150.png\" alt=\"\" class=\"has-border-color has-accent-3-border-color wp-image-579\" style=\"border-width:6px;border-top-left-radius:100px;border-top-right-radius:100px;border-bottom-left-radius:100px;border-bottom-right-radius:100px\" srcset=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/singlecell-e1771765470654-150x150.png 150w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/singlecell-e1771765470654-300x300.png 300w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/singlecell-e1771765470654.png 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Single-cell_resolution_of_clinically_interpretable_transcription_programs\"><\/span><strong>Single-cell resolution of clinically interpretable transcription programs<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Joint analysis of single-cell and bulk RNA-seq toward the study of clinically informative gene expression (leveraging clinically annotated bulk-profiles biopsies) at the single-cell resolution (leveraging single-cell RNA-seq)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-thumbnail has-custom-border is-style-rounded is-style-rounded--3\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/evomod-e1771765645848-150x150.png\" alt=\"\" class=\"has-border-color has-accent-3-border-color wp-image-580\" style=\"border-width:6px;border-top-left-radius:100px;border-top-right-radius:100px;border-bottom-left-radius:100px;border-bottom-right-radius:100px\" srcset=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/evomod-e1771765645848-150x150.png 150w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/evomod-e1771765645848-300x300.png 300w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/evomod-e1771765645848.png 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Evolutionary_Models\"><\/span><strong>Evolutionary Models<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Developing novel computational methods to study cancer evolution while encompassing clonal dynamics (DNA-level) and epigenetic adaptation.<\/p>\n\n\n\n<p><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-thumbnail has-custom-border\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/medinfo-e1771765675797-150x150.png\" alt=\"\" class=\"has-border-color has-accent-3-border-color wp-image-581\" style=\"border-width:6px;border-top-left-radius:100px;border-top-right-radius:100px;border-bottom-left-radius:100px;border-bottom-right-radius:100px\" srcset=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/medinfo-e1771765675797-150x150.png 150w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/medinfo-e1771765675797-300x300.png 300w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/medinfo-e1771765675797.png 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Medical_Informatics\"><\/span><strong>Medical Informatics<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Leveraging Machine Learning (ML) strategies to improve patient stratification in precision oncology and precision medicine.<\/p>\n\n\n\n<p><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-thumbnail has-custom-border is-style-rounded is-style-rounded--4\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/digpath-e1771765698940-150x150.png\" alt=\"\" class=\"has-border-color has-accent-3-border-color wp-image-582\" style=\"border-width:6px;border-top-left-radius:100px;border-top-right-radius:100px;border-bottom-left-radius:100px;border-bottom-right-radius:100px\" srcset=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/digpath-e1771765698940-150x150.png 150w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/digpath-e1771765698940-300x300.png 300w, https:\/\/fohs.bgu.ac.il\/ocohenlab\/wp-content\/uploads\/2026\/02\/digpath-e1771765698940.png 600w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Digital_Pathology\"><\/span><strong>Digital Pathology<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Computational pathology and histology using foundation models to infer clinical biomarkers and morphological archetypes from H&amp;E whole-slide images and related modalities.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tackling evolved drug resistance in advanced tumors Our computational oncology lab spans several research directions in evolution, precision medicine, and oncology. These directions are directed toward improving patient care and providing a better understanding of the fundamental processes that govern the evolution of drug resistance in advanced malignancies. Transcriptional Archetypes Characterization of the entire \u201clandscape\u201d [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Ofir Cohen\u2019s lab of Computational Oncology - Ofir Cohen Lab<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/fohs.bgu.ac.il\/ocohenlab\/\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Ofir Cohen\u2019s lab of Computational Oncology - Ofir Cohen Lab\" \/>\r\n<meta property=\"og:description\" content=\"Tackling evolved drug resistance in advanced tumors Our computational oncology lab spans several research directions in evolution, precision medicine, and oncology. 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