Prof. Michael Danilenko

Prof. Michael Danilenko Profile

Researcher A
PhD., 1985

Researcher

Department : Clinical Biochemistry and Pharmacology
Medical Laboratory Sciences
Room : 6032
כירורגית
Phone : 972-8-6479969
Email : misha@bgu.ac.il
Office Hours :  
cancer, cell biology, bio chemistry

Education

  • M.Sc. (Physiology) 1973-1977 - Dept. of Physiology, The Kazakh State University, Almaty, Kazakhstan.
  • Ph.D. (Biochemistry) 1985 - Institute of Biochemistry and Molecular Biology, Kazakh Academy of Sciences, Almaty, Kazakhstan Thesis: "Cholinergic regulation of Na+,K+-ATPase activity"

Research Interests

  • Anti-cancer activity of plant antioxidants and their combinations with differentiation-inducing agents

Research Topics

  • Translational studies on combination therapy and prevention of AML and other types of cancer by phytochemicals and vitamin derivatives
  • Synergistic differentiation induction by vitamin D or retinoic acid derivatives and phytochemicals ( eg , plant polyphenols)
  • Selective growth arrest and cytotoxicity by synergistic combinations of phytochemicals

Major expertise and techniques in the lab

  • Cancer cell biology
  • Flow cytometry & standard biochemical methods

Publications and funding summary / representative publications and grants

  • Pesakhov S, Khanin M, Studzinski GP, Danilenko M . Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid and silibinin on proliferation and apoptosis in acute myeloid leukemia cells. Nutr Cancer, 2010, 62: 811-824 .
  • Bobilev I, Novik V, Levi I, Shpilberg O, Levy J, Sharoni Y, Studzinski GP, Danilenko M . The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells. Cancer Biol Ther , 11:317-329, 2011.
  • Recent grants and existing collaborations:
  • American Institute for Cancer Research (2011– 2012) – “Plant antioxidant combinations in leukemia: a cell-based model for cancer prevention”, with George P. Studzinski (UMDNJ) & Itai Levi (Hematology).
  • Israel Science Foundation (2011-2015) – “Interplay between vitamin D derivatives and plant polyphenols in differentiation therapy of acute myeloid leukemia”, with Yoav Sharoni, Itai Levi, Netta Sion -Vardy (Pathology) & Michael Friger (Epidemiology).
  • NIH/NCI - RO1 (2007-2011) – “Vitamin D and plant antioxidant silibinin in leukemia: translational study”, with George P. Studzinski, Itai Levi, Netta Sion -Vardy & Michael Friger .
  • Daniel Fishman (Morphology), Israel Sekler (Physiology) & Shimon Ben-Shabat (Pharmacology) – Synergistic targeting of Ca 2+ /Zn 2+ homeostasis in cancer cells by cytotoxic combinations of plant polyphenols.

Suggested multi-disciplinary research project / research focus topics

  • Clinical studies on therapy/prevention of cancer by combinations of natural compounds.

Additional links