Prof. Galila Agam

Prof. Galila Agam Profile

Associate Professor Retired
Ph.D., 1984

Department : Clinical Biochemistry and Pharmacology
Zlotowski Center for Neurosciences
Clinical Biochemistry and Pharmacology
Zlotowski Center for Neurosciences
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Brain, Bipolar-disorder, Mood-disorders, Biochemistry, Mood-stabilization, Mitochondria, Autophagy, Lithium


  • B.Sc. Chemistry, Biochemistry 1965-1968 Hebrew University, Jerusalem
  • M.Sc. Medical Sciences/Biochemistry 1968-1970, Hebrew University Medical School, Jerusalem.
  • Ph.D. 1980-1984, Ben-Gurion University of the Negev, Beer Sheva 
  • B.S.W. 1989-1995, Ben-Gurion University of the Negev, Beer Sheva


Research Interests

  • Bipolar disorder and its treatment
  • The possible involvement of mitochondrial dysfunction in the etiology of neuropsychiatric disorders
  • Mechanism of mood stabilization
  • Interaction among neuroinflammation, brain mitochondrial function and brain autophagy


Research Topics

  • The etiology of bipolar disorder
  • The molecular mechanism of mood stabilization
  • The possible involvement of autophagy in mood stabilization

Publications and funding summary / representative publications and grants

1: Agam G, Azab AN. Whether lithium inhibits glycogen synthase kinase (GSK)-3?
activity in vivo in humans is still an open question. Bipolar Disord. 2016
Aug;18(5):464-7. doi: 10.1111/bdi.12414. Epub 2016 Jul 21. PubMed PMID: 27440170.

2: Toker L, Agam G. Mitochondrial dysfunction in psychiatric morbidity: current
evidence and therapeutic prospects. Neuropsychiatr Dis Treat. 2015 Sep
24;11:2441-7. doi: 10.2147/NDT.S70346. eCollection 2015. Review. PubMed PMID:
26442764; PubMed Central PMCID: PMC4590577.

3: Agam G. Current hypotheses of lithium's mechanism of action as a
neuropsychiatric medication. ACS Chem Neurosci. 2014 Jun 18;5(6):410. doi:
10.1021/cn5001183. PubMed PMID: 26054372; PubMed Central PMCID: PMC4063505.

4: Agam G, Almog O. Calbindin D28k and S100B have a similar interaction site with
the lithium-inhibitable enzyme inositol monophosphatase-1: a new drug target
site. J Med Chem. 2015 Feb 26;58(4):2042-4. doi: 10.1021/jm5019324. Epub 2015 Feb
16. PubMed PMID: 25665147.

5: Kara N, Narayanan S, Belmaker RH, Einat H, Vaidya VA, Agam G. Chronic Lithium
Treatment Enhances the Number of Quiescent Neural Progenitors but Not the Number
of DCX-Positive Immature Neurons. Int J Neuropsychopharmacol. 2015 Jan
29;18(7):pyv003. doi: 10.1093/ijnp/pyv003. PubMed PMID: 25636892; PubMed Central
PMCID: PMC4540105.

6: Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E,
Dean B, Levine J, Agam G, Gozes I. Autophagy has a key role in the
pathophysiology of schizophrenia. Mol Psychiatry. 2015 Feb;20(1):126-32. doi:
10.1038/mp.2013.174. Epub 2013 Dec 24. PubMed PMID: 24365867; PubMed Central
PMCID: PMC4320293.

7: Toker L, Bersudsky Y, Plaschkes I, Chalifa-Caspi V, Berry GT, Buccafusca R,
Moechars D, Belmaker RH, Agam G. Inositol-related gene knockouts mimic lithium's
effect on mitochondrial function. Neuropsychopharmacology. 2014 Jan;39(2):319-28.
doi: 10.1038/npp.2013.194. Epub 2013 Aug 8. PubMed PMID: 23924600; PubMed Central
PMCID: PMC3870788.


Existing collaborations

  • Yuly Bersudsky/Joseph Levin – clinical and basic studies of the molecular mechanism of mood stabilization and the etiology of bipolar disorder.
  • Abed Azab – neuroinflammation and mood stabilization.
  • Orian Shirihai/Guy Las – brain autophagy.
  • Hava Golan – treatment of autism in animal models.

Additional links