Prof. Assaf Rudich

Prof. Assaf Rudich Profile

M.D., 1994 Ph.D. 1999

Department : Clinical Biochemistry and Pharmacology
S. Daniel Abraham International Center for Health and Nutrition
Room : 217
בנין פתולוגיה
Phone : 972-8-6479934
Email :
Office Hours :  
The role of adipose tissue dysfunction in obesity and its co-morbidities


  • M.D. 1987-1994, Ben-Gurion University, the Faculty of Health Sciences. M.D. thesis: Advisors: Prof. Rachel Levy, Prof. Yair Liel. Title: “A cellular model for studying macrophage function in Gaucher’s disease”. Medical Internship 1994-1995, Soroka Medical Center, Beer-Sheva, Israel. Ph.D. 1995-1999, Ben-Gurion University, Department of Clinical Biochemistry. Advisors: Prof. Nava Bashan, Prof. Moshe Philip. Title: "Reactive oxygen species as modulators of glucose metabolism and insulin signaling: relevance to peripheral insulin resistance". Post-doctoral 2001-2004, training and Visiting scientist, The Hospital for Sick Children, Programme in Cell Biology, Toronto, Canada. Advisor: Prof. Amira Klip. Title: “Temporal-spatial regulation of 3-phosphoinositide production by insulin”.

Research Projects

Research Topics

  • Adipose tissue contribution to obesity-related diseases
  • Cell biology of adipocytes
  • Insulin signaling iv. Inflammatory basis of obesity

Major expertise and techniques in the lab

  • Cellular, inter-organ and whole-body metabolism
  • Human adipose tissue bank
  • Biochemistry, molecular biology, imaging of adipose tissues, adipocytes, and liver

Publications and funding summary / representative publications and grants

  • J. Kovsan, M. Bl ? her, T. Tarnovscki, N. Kl ? ting, B. Kirshtein, L. Madar,
  • Shai, R. Golan,
  • Harman-Boehm, M. R. Schon, A. S. Greenberg, Z. Elazar, N. Bashan, A. Rudich . Altered autophagy in human adipose tissues in obesity. J. Clin. Endocrinol. Metab. 96: E268-E277, 2011.
  • H. Ovadia, Y. Haim, O. Nov, O. Almog, J. Kovsan, N. Bashan, M. Benhar, and A. Rudich. Increased adipocytes S- nitrosylaion targets the anti-lipolytic action of insulin: relevance to adipose tissue dysfunction in obesity. J . Biol. Chem., 286: 30433-30443, 2011.
  • A. Tirosh,
  • Shai, A. Afek, G. Dubnov-Raz, N. Ayalon, B. Gordon, E. Derazne, D. Tzur, A. Shamis, S. Vinker, and A. Rudich . Adolescent BMI trajectory and risk of diabetes versus coronary disease. New Engl. J. Med., 364: 1315-25, 2011. iv. E. Shemesh, A. Rudich* ,
  • Harman-Boehm, T. Cukierman-Yaffe. Effect of intranasal insulin on cognitive function – a systematic review. J. Clin. Endocrinol. Metab. 97: 366-376, 2012.

Existing collaborations

  • Iris Shai, Ilan Shelef, Ilana Harman-Boehm, Yaakov Henkin, Taly Wolak – lifestyle interventional studies targeting obesity and cardio-metabolic risk
  • Ron Apte, Eli Lewis – role of IL-1b in adipose-liver crosstalk

Suggested multi-disciplinary research project / research focus topics

  • Cardiometabolic health
  • Health and Environment
  • Metabolic inflammation and its role in non-metabolic diseases