Tumor Microenvironment

Extracellular vesicles

Mutations in p53

Cancer microbiome

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC. Mutant p53 cancers reprogram tumor associated macrophages via exosomal miR-1246. Nature Comm. 2018;9(1):771. doi: 10.1038/s41467-018-03224-w.

Greathouse LK, White JR, Vargas AJ, Bliskovsky VV, Beck JA, Von Muhlinen N, Polley E, Bowman ED, Robles AI, Khan MA, Robles AI, Cooks T, Ryan BM, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC. Microbiome-TP53 Gene Interaction in Human Lung Cancer. Genome Biol. 2018;19(1):123. doi: 10.1186/s13059-018-1501-6.

Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano GC, Pikarsky E, Forshew T, Rosenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M. Mutant p53 Prolongs NF-?B Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer. Cancer Cell. 2013; 23(5):634-46.