Prof. Claude Brodski

Prof. Claude Brodski Profile

Associate Professor
M.D. 2005

Department : Physiology and Cell Biology
Room : 332
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם
Phone : 972-8-6477311
Email :
Office Hours :  
Development, survival and degeneration of dopaminergic neurons, Parkinson's disease, drug development


  • 1995 M.D. Technichal University of Munich
  • 1999 Doctorate, summa cum laude, Dept. Neurobiochemistry, Max-Planck  Institute of Neurobiology

Research Interests

The goal of our lab is to advance our knowledge of the molecular mechanisms controlling the development, survival and degeneration of dopaminergic neurons and to develop drugs for dopamine associated disorders including Parkinson's disease. 

Research Topics

  • Molecular mechanisms controlling the development, survival and degeneration of dopaminergic neurons
  • Neurotrophic Factors as drug candidates

Publications and funding summary / representative publications and grants

  • Masana M, Jukic MM, Kretzschmar A, Wagner KV, Westerholz S, Schmidt MV, Rein T, Brodski C, Muller MB. Deciphering the spatio-temporal expression and stress regulation of Fam107B, the paralog of the resilience-promoting protein DRR1 in the mouse brain. Neuroscience. 2015 Apr 2;290:147-58.
  • Jukic MM, Carrillo-Roa T, Bar M, Becker G, Jovanovic VM, Zega K, Binder EB, Brodski C. Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder. Neuropsychopharmacology. 2015 Mar;40(4):839-48
  • Kayam G, Kohl A, Magen Z, Peretz Y, Weisinger K, Bar A, Novikov O, Brodski C, Sela-Donenfeld D. A novel role for Pax6 in the segmental organization of the hindbrain. Development. 2013 May;140(10):2190-202
  • Boell L, Pallares LF, Brodski C, Chen Y, Christian JL, Kousa YA, Kuss P, Nelsen S, Novikov O, Schutte BC, Wang Y, Tautz D. Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation. Dev Genes Evol. 2013 Sep;223(5):279-87.
  • Tilleman H., Hakim V., Novikov N, Liser K, Nashelsky L, Di Salvio M., Krauthammer M., Scheffner O., Maor I., Mayseless O., Meir I., Kayam G., Sela-Donenfeld D., Simeone A. and Brodski C. Bmp5/7 in concert with the mid-hindbrain organizer control the development of noradrenergic locus coeruleus neurons Molecular and Cellular Neuroscience (MCN), 2010, 45(1):1-11
  • Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, Sekler I, Silverman WF. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. Journal of Cellular Physiology, 2010, 224(3):567-74.
  • Tilleman H, Kofman O, Nashelsky L, Livneh U, Roz N, Sillaber I, Biegon A, Rehavi M, Brodski C. Critical role of the embryonic mid-hindbrain organizer in the behavioral response to amphetamine and methylphenidate. Neuroscience, 2009, 163(4):1012-23.
  • Apostolova G, Dorn R, Ka S, Hallbook F, Lundeberg J, Liser K, Hakim V, Brodski C, Michaelidis TM, Dechant G. Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons. Molecular and Cellular Neuroscience (MCN), 2007, 35(3):397-408.
  • Prakash N, Brodski C (co-first author), Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Vogt Weisenhorn DM, Martinez S, Arenas E, Simeone A and Wurst W A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo Development, 2006, 133(1):89-98.
  • Panhuysen M, Vogt Weisenhorn DM, Blanquet V, Brodski C, Heinzmann U, Beisker W, Wurst W Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region. Molecular and Cellular Neuroscience (MCN), 2004, 26(1):101-11.
  • Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A. Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development, 2004, 131(9):2037-48.
  • Brodski C, Vogt Weisenhorn D, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the mid-hindbrain organizer Journal of Neuroscience, 2003, 23(10):4199-207
  • Brodski C, Vogt Weisenhorn DM, Dechant G. Therapy of neurodegenerative diseases using neurotrophic factors: cell biological perspective Expert Review of Neurotherapeutics, 2002, (3):417-426
  • Pfaar H, von Holst A, Vogt Weisenhorn DM, Brodski C, Guimera J, Wurst W. mPet-1, a mouse ETS-domain transcription factor is expressed in central serotonergic neurons Development, Genes and Evolution, 2002, 212(1):43-6
  • Brodski C, Schaubmar A, Dechant G. Opposing function of GDNF and NGF in the development of cholinergic and noradrenergic sympathetic neurons Molecular and Cellular Neuroscience (MCN), 2002, 19(4):528-38
  • Brodski C, Schnurch H, Dechant G. Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons. Proceedings of the National Academy of Science of the U S A. (PNAS), 2000, 97(17):9683-8
  • Maier W, Minges J, Eckstein N, Brodski C, Albus M, Lerer B, Hallmayer J, Fimmers R, Ackenheil M, Ebstein RE, Borrmann M, Lichtermann D, Wildenauer DB. Genetic relationship between dopamine transporter gene and schizophrenia: linkage and association. Schizophrenia Research, 1996, 20(1-2):175-80.

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