Prof. Roni Apte

Prof. Roni Apte Profile

Professor Emeritus
Ph.D. 1978

Department : Shraga Segal Department of Microbiology, Immunology and Genetics
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inflammation, il 1, cancer,angiogenesis, immuotherapy, stem cells, reprogramming, differention


  • 1970-1973 B.Sc. Magna Cum Laude, Bar-Ilan University, Ramat Gan,Israel, Dept. of Life Sciences, Microbiology. 1973-1978
  • Ph.D. student, Bar-Ilan University, Dept. of Life Sciences, Supervisor: Prof. D. H. Pluznik. Thesis: "Regulation of Granulopoiesis and macrophage formation by bacterial lipopolysaccharides".

Research Interests

  • Tumor immunobiology
  • tumor immunotherapy
  • cytokine biology
  • IL-1 biology in steady state homeostasis and in disease (focus is on inflammatory diseases and cancer
  • the intracrine role of IL-1 in fibroblasts

Research Topics

  • The role of inflammation in the malignant process- Basic Issues and Translational studies
  • Biology of the cytokine Interleukin-1 (IL-1) in health and disease
  • Novel signaling pathways of IL1 alpha in the nucleus
  • The role of inflammation on the biology of cancer stem cells
  • The effects of inflammation on induced pluripotent stem cells (iPS) and embryonic stem cells (ESCs)

Major expertise and techniques in the lab

  • Animal work
  • Tissue culture
  • Molecular biology techniches

Publications and funding summary / representative publications and grants

  • Apte RN, Voronov E Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy? Immunol Rev.222:222-41.
  • Cohen I, Rider P, Carmi Y, Braiman A, Dotan S, White MR, Voronov E, Martin MU, Dinarello CA, Apte RN. 2010. Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2574-9.
  • Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN. 2011. IL-1? and IL-1? recruit different myeloid cells and promote different stages of sterile inflammation. J Immunol. 2011 Nov 1;187(9):4835-43.
  • Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN. 2012. The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells. Front Immunol. 2012;3:290.
  • Ministry of Health, Chief Scientist office, European Community (FP7), Israel-US binational fund (BSF),
  • Israel Science Foundation (ISF),
  • Tahstiot- Ministry of Science, Technology and Sports, Cooperation program of the Ministry of
  • Science, Technology and Sports together with the German Cancer Institute in Heidelberg

Existing collaborations

    • Suggested multi-disciplinary research project / research focus topics

      • Prof. Jonathan Leeor- Sheba Hospital and TAU- Control of inflammation as mean to reduce the damage following myocardial infarction (MI)
      • Dr. Yehuda Kamari- Sheba Hospital and TAU- The role of IL-1 in atherosclerosis and fatty liver development
      • Prof. Assaf Rudich- Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, BGU- The role of IL-1-mediated inflammation on the development of the metabolic syndrome and Diabetes type II
      • Dr. Rivka Ofir- The Shraga Segal Department of Microbiology, Immunology and Genetics- Faculty of Health Sciences, BGU- The role of IL-1 induced inflammation in reprogramming and pluripotent stem cells and in their differentiation.

      Looking for expertise / project

      • Advanced molecular biology and bioinformatics