Associate Professor
PhD.,2002
School Director
pharmacology, pharmaco kinetics, pharmaco dynamics, nano medicine, bio pharmaceuticals |
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- 1997-2002 PhD studies at Dept. of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem. Thesis: Optimization of mode of drug administration according to pharmacodynamic rationale. Graduated Summa cum Laude. Supervisors: Prof. Amnon Hoffman, Prof. Michael Friedman. 1996-1997 M.Sc.Pharm. studies at Dept. of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem. Thesis: Bisphosphonate pharmacokinetics and screening of bisphosphonate activity in a bone cancer model. Supervisor: Prof. Amnon Hoffman. 1992-1996 B.Sc.Pharm. studies at School of Pharmacy, The Hebrew University of Jerusalem. 1988-1991 Medicine studies at medical faculty, The 2nd Moscow Medical College.
- Intracellular targeting of biopharmaceuticals using nanotechnologies. Delivery systems and their effects on the biopharmaceuticals’ pharmacokinetics and pharmacodynamics. PK-PD modeling. Protein interactions and protein balance within the endoplasmic reticulum and the ER stress. Fluorescent imaging and biochemical characterization of the protein interactions within the MHC class I peptide loading complex and of the antigen presentation pathways.
- Delivery systems and their effects on the biopharmaceutical's pharmacokinetics and pharmacodynamics
- Drug delivery and targeting, controlled release dosage forms
- Preclinical and clinical pharmacokinetics and pharmacodynamics, PK/PD modeling iv. Intracellular targeting of biopharmaceuticals using nanotechnologies
Major expertise and techniques in the lab
- Preclinical and clinical pharmacokinetics and pharmacodynamics, PK-PD modeling
- Drug absorption and permeability, controlled release dosage forms (nanoparticles, liposomes)
- Fluorescence imaging and advanced algorithms for image analysis (confocal microscopy, FRET, FRAP) iv.Biochemistry, experimental immunology, molecular biology, tissue culture v.Analytical methods development and validation (HPLC, GC, etc.) v
- Quality control of pharmaceuticals and medical devices
Publications and funding summary / representative publications and grants
- Sneh-Edri H, Likhtenshtein D, Stepensky D. Intracellular targeting of PLGA nanoparticles encapsulating antigenic peptide to the endoplasmic reticulum of dendritic cells and its effect on antigen cross-presentation in vitro. Mol Pharmaceutics 2011; 8(4):1266-75.
- Dakwar G, Hammad IA, Popov M, Linder C, Grinberg S, Heldman E, Stepensky D. Delivery of proteins to the brain by bolaamphiphilic nano -sized vesicles. J Control Release 2012, in press.
- Stepensky D. Local vs. systemic anti-TNF-alpha effects of adalimumab in rheumatoid arthritis: pharmacokinetic modeling analysis of interaction between a soluble target and a drug. Clin Pharmacokinet 2012, in press.
- Eli Heldman (Clinical Biochemistry, BGU) & collaborators - brain-targeted delivery of drugs
using bolavesicular drug delivery systems
- Alex Zlotnik (Anesthesiology, Soroka ) – glutamate neurotoxicity and neuroprotection
- Amir Sagi (Life Sciences, BGU) - calcium supplements for treatment and prevention of osteoporosis
Looking for expertise / project
- Clinical projects of biopharmaceutical drug development, such as anti-cytokine antibodies in rheumatoid arthritis