Researcher A
PhD., 1985
Researcher
cancer, cell biology, bio chemistry |
|
|
- M.Sc. (Physiology) 1973-1977 - Dept. of Physiology, The Kazakh State University, Almaty, Kazakhstan.
- Ph.D. (Biochemistry) 1985 - Institute of Biochemistry and Molecular Biology, Kazakh Academy of Sciences, Almaty, Kazakhstan Thesis: "Cholinergic regulation of Na+,K+-ATPase activity"
- Anti-cancer activity of plant antioxidants and their combinations with differentiation-inducing agents
- Translational studies on combination therapy and prevention of AML and other types of cancer by phytochemicals and vitamin derivatives
- Synergistic differentiation induction by vitamin D or retinoic acid derivatives and phytochemicals ( eg , plant polyphenols)
- Selective growth arrest and cytotoxicity by synergistic combinations of phytochemicals
Major expertise and techniques in the lab
- Cancer cell biology
- Flow cytometry & standard biochemical methods
Publications and funding summary / representative publications and grants
- Pesakhov S, Khanin M, Studzinski GP, Danilenko M . Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid and silibinin on proliferation and apoptosis in acute myeloid leukemia cells. Nutr Cancer, 2010, 62: 811-824 .
- Bobilev I, Novik V, Levi I, Shpilberg O, Levy J, Sharoni Y, Studzinski GP, Danilenko M . The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells. Cancer Biol Ther , 11:317-329, 2011.
- Recent grants and existing collaborations:
- American Institute for Cancer Research (2011– 2012) – “Plant antioxidant combinations in leukemia: a cell-based model for cancer prevention”, with George P. Studzinski (UMDNJ) & Itai Levi (Hematology).
- Israel Science Foundation (2011-2015) – “Interplay between vitamin D derivatives and plant polyphenols in differentiation therapy of acute myeloid leukemia”, with Yoav Sharoni, Itai Levi, Netta Sion -Vardy (Pathology) & Michael Friger (Epidemiology).
- NIH/NCI - RO1 (2007-2011) – “Vitamin D and plant antioxidant silibinin in leukemia: translational study”, with George P. Studzinski, Itai Levi, Netta Sion -Vardy & Michael Friger .
- Daniel Fishman (Morphology), Israel Sekler (Physiology) & Shimon Ben-Shabat (Pharmacology) – Synergistic targeting of Ca 2+ /Zn 2+ homeostasis in cancer cells by cytotoxic combinations of plant polyphenols.
Suggested multi-disciplinary research project / research focus topics
- Clinical studies on therapy/prevention of cancer by combinations of natural compounds.