Dr. Daniel Fishman

Dr. Daniel Fishman Profile

Senior lecturer
MD: 1988 Ph.D. 1999

Department : Physiology and Cell Biology
Room : 331
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם
Phone : 972-8-6477314
Email : dmitrif@bgu.ac.il
Office Hours :  
cancer, melanoma


  • Ph.D. 1991- 1999 – Ben-Gurion University of the Negev, Beer-Sheva Thesis : Signal transduction transgression and transcriptional derangements In metastatic and non-metastatic tumor cell variants Summa cum laude Supervisor: Prof. S. Segal M.D. 1982 – 1988 – State Institute of Medicine, Chelyabinsk, USSR

Research Interests

Research Topics

  • Melanoma cell biology and physiology
  • Lipid rafts and tumor-promoting Ca 2+ -signaling in malignant cells

Major expertise and techniques in the lab

  • Signal transduction and Ca2+-signaling
  • Confocal microscopy
  • Flow cytometry

Publications and funding summary / representative publications and grants

  • Fedida-Metula S, Feldman B, Koshelev V, Levin-Gromiko U, Voronov E, Fishman D (2012) Lipid rafts couple store-operated Ca2+-entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway, and promote melanoma tumor growth. Carcinogenesis . doi: 10.1093/carcin/bgs021 P2.
  • Feldman B, Fedida-Metula S, Nita J, Sekler I, Fishman D (2010) Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells. Cell Calcium .47(6):525-37 P3.
  • Fedida-Metula S, Elhyany S, Tsory S, Segal S, Hershfinkel M, Sekler I, Fishman D. Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells. Carcinogenesis . 2008 Aug;29(8):1546-54. F1.
  • 2010 – 2012 Israeli Ministry of Health grant on “The potential application of agents targeting cellular cholesterol and calcium-driven oncogenic signaling in melanoma therapy".
  • 2008 – 2012 Israel Science Foundation grant “A novel approach to eradicate melanoma: targeting membrane micro-domains by cholesterol depletion inhibits PKB by disrupting calcium homeostasis and restrains tumor growth”.

Existing collaborations

  • Michael Danilenko – targeting AML via disruption of Ca2+ homeostasis

Suggested multi-disciplinary research project / research focus topics

  • Cancer research