Prof. Adrian Israelson

Prof. Adrian Israelson Profile

Associate Professor
Ph.D. 2007

Department : Physiology and Cell Biology
Room : 432
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם
Phone : 972-8-6477334
Email :
Office Hours :  
als, neuro degenerative diseases, misfolded proteins, mitochondrial dysfunction, neurology, physiology


  • 2007-2012 Postdoctoral fellow, laboratory of Prof. Don Cleveland, Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, The University of California San Diego. La Jolla, CA, USA.
  • 2001-2007 Ph.D. Summa cum laude, Biochemistry. Department of Life Sciences, Ben Gurion University of the Negev, Israel.
  • 1998-2001 B.Sc. Biology (Major-Biochemistry). Department of Life Sciences, Ben Gurion University of the Negev, Israel.

    Research Topics

    • Molecular mechanisms of neurodegeneration
    • Misfolded proteins in neurodegenerative diseases
    • Misfolded SOD1 toxicity in ALS
    • Mitochondrial dysfunction in ALS

    Major expertise and techniques in the lab

    • Biochemistry and molecular biology
    • Molecular genetics
    • ALS models

    Publications and funding summary / representative publications and grants

              Representative Publications:

    • Israelson A , Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V and Cleveland DW. Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron 67, 575-587 (2010).
      Comments on this article:
      i. Highlighted in Neuron with a preview article.
      ii. Featured in Nature as Research Highlights
      iii. Featured in Nature Medicine as Research Highlights.
      iv. Recommended by “Faculty of 1000” .
    • Li Q*, Vande Velde C*, Israelson A , Xie J, Bailey AO, Dong M, Chun S, Roy T, Yates JR., Capaldi RA, Cleveland DW and Miller TM. ALS-linked mutant superoxide dismutase 1(SOD1) alters mitochondrial protein composition and decreases protein import. PNAS 107, 21146-21151 (2010).
    • Agam G and Israelson A . Why lithium studies for ALS treatment should not be halted prematurely. Front. Neurosci 8, 267 (2014).
    • Getter T, Zaks I, Barhum Y, Ben-Zur T, B?selt S, Gregoire S, Viskind O, Shani T, Gottlieb H, Green O, Shubely M, Senderowitz H, Israelson A , Kwon I, Petri S, Offen D and Gruzman A. A novel chemical chaperone-based drug candidate is effective in mouse model of amyotrophic lateral sclerosis (ALS). ChemMedChem . 10, 850-861 (2015).
    • Israelson A#, Ditsworth D, Sun S, Song SW, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S and Cleveland DW#. Macrophage Migration Inhibitory Factor (MIF) as a Chaperone Inhibiting Accumulation of Misfolded SOD1. Neuron 86, 218-232 (2015). #corresponding author
       Comments on this article:
      Highlighted in Neuron with a preview article. 
      Recommended by “Faculty of 1000”          

    • Leyton-Jaimes M*, Benaim C*, Abu-Hamad S*, Guetta A, Kahn J, Bucala R, and Israelson A. Endogenous Macrophage Migration Inhibitory Factor Reduces the Accumulation and Toxicity of Misfolded SOD1 in a Mouse Model of ALS. PNAS 113, 10198-10203 (2016).
    • Banerjee V*, Shani T, Katzman B, Vyazmensky M, Papo N, Israelson A and Engel S. SOD1–derived peptide inhibits amyloid-like aggregation of misfolded SOD1. ACS Chem. Neurosci. 7, 1595-1606 (2016).
    • Shani T, Levy M, and Israelson A. Assay to measure nucleocytoplasmic transport in real time using motor neuron-like NSC-34 cells. J. Vis. Exp. 123, e55676 (2017).
    • Abu-Hamad S, Kahn J, Leyton-Jaimes M, Rosenblatt J and Israelson A. Misfolded SOD1 accumulation and mitochondrial association contribute to the selective vulnerability of motor neurons in familial ALS: correlation to human disease. ACS Chem. Neurosci. 8, 2225-2234 (2017).
    • Leyton-Jaimes M, Kahn J and Israelson A. Macrophage Migration Inhibitory Factor: A Multifaceted Cytokine Implicated in Multiple Neurological Diseases. Exp. Neurol. 301, 83-91 (2018).
    • Shvil N, Banerjee V,  Zoltsman G, Shani T, Kahn J, Abu-Hamad S, Papo N, Engel S, Bernhagen J and Israelson A. MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: Implications for familial ALS. Cell Death & Disease 9, 107 (2018).

    Representative Grants:

    1. 2011-2014- Muscular Dystrophy Association (MDA) development grant
    2. 2013-2014 - The Israeli ALS association (IsrALS)
    3. 2013-2017- Marie curie career integration grants funded by the European Commission (people programme, FP7)
    4. 2014– 2015 - The German-Israeli Foundation (GIF)
    5. 2014– 2016 - Bi-National Science Foundation (BSF)
    6. 2014– 2019 - Israel Science Foundation (ISF), individual research grant
    7. 2014– 2019 - Israel Science Foundation (ISF), lab equipment for new faculty member
    8. 2014 – 2015 - National Institute for Psychobiology in Israel (NIPI)
    9. 2015– 2018 – EuroNanoMed, Consortium research grant
    10. 2018- 2021- Bi National Science Foundation (BSF)
    11. 2019- 2022- The German-Israeli Foundation (GIF)