Prof. Esti Yeger-Lotem

Prof. Esti Yeger-Lotem Profile

Associate Professor

Head of Department

Department : Clinical Biochemistry and Pharmacology
Room : 217
בניין המכון הלאומי לביוטכנולוגיה בנגב, ע"ש אדגר דה-פיצ'וטו - 41
Phone : 972-74-7728675
Email :
Office Hours :  
Bioinformatics, network biology, computational systems biology, protein interactions, transcriptome and RNA sequencing analysis, data integration, Par


  • Ph.D. 2005

Research Interests

  • Bioinformatics
  • Network biology
  • Computational systems biology
  • Protein interactions
  • Transcriptome and RNA sequencing analysis
  • Data integration
  • Parkinson's disease
  • Melanoma
  • Yeast response pathways

Research Topics

  • Computational systems biology of human tissues
  • Tissue-selectivity of genetic diseases
  • Identifying the cellular pathways underlying complex diseases (Alzheimer disease, Parkinson disease, melanoma)
  • The yeast signaling network

Major expertise and techniques in the lab

  • Bioinformatics/computational systems biology
  • Network biology (human tissues, yeast) Pathway analysis (complex diseases, environmental responses)
  • Large-scale data integration (next generation sequencing, molecular interactions, screening)

Publications and funding summary / representative publications and grants

  • Yeger-Lotem E., Riva L., Su L.J., Gitler A., Cashikar A., King O.D., Auluck P.K., Geddie M.L., Valastyan J.S., Karger D.R., Lindquist S., Fraenkel E. 2009. Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity. Nature Genetics 41: 316 - 323 .
  • Barshir R., Shwartz O., Smoly I.Y. and Yeger-Lotem E. 2014.  Comparative analysis of human tissue interactomes reveals factors leading to tissue-specific manifestation of hereditary diseases.  PLoS Computational. Biology 10(6):e1003632
  • Grants from IRG, BSF, Israel Cancer Association, ISF, Broad-ISF

Looking for expertise / project

  • Complex diseases – identification of cellular pathways underlying disease

Additional links