Prof. Yoav Sharoni
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Professor
Department :
Clinical Biochemistry and Pharmacology
School of Pharmacy
Room :
6028
Phone :
972-8-6479936
Email :
Yoav@bgu.ac.il
Office Hours :
Education
1966-1969
B.S
with distinction (Chemistry), Hebrew University of Jerusalem. 1970-1971
M.S
(Biochemistry), Department of Biological Chemistry, Hebrew University of Jerusalem. Adviser: Prof. E. Dimant. Thesis Title: The Metabolism of D-Erythrose in the rat. 1972-1977
Ph.
(Biochemistry), Department of Biological Chemistry, Hebrew University of Jerusalem. Adviser: Prof. M. Schramm. Thesis Topic: Morphological and Biochemical changes in secretory granules from the rat parotid gland. 1966-1969 B.Sc. with distinction (Chemistry), Hebrew University of Jerusalem. 1970-1971 M.Sc. (Biochemistry), Department of Biological Chemistry,Hebrew University of Jerusalem. Adviser: Prof. E. Dimant. Thesis Title: The Metabolism of D-Erythrose in the rat. 1972-1977 Ph.D. (Biochemistry), Department of Biological Chemistry, Hebrew University of Jerusalem. Adviser: Prof. M. Schramm. Thesis Topic: Morphological and Biochemical changes in secretory granules from the rat parotid gland.
Research Interests
Clinical or research interests: Nutrition and cancer: The effect of dietary derived compounds and hormones on molecular changes and transcription systems in cancer cells. Regulation of transcription by carotenoids. The elucidation of the role of oxidation products and metabolites of tomato carotenoids in cancer prevention and the activation of various transcription systems by the carotenoids and their derivatives. Part of this project is done in collaboration with W. Stahl from Heinrich Heine University D?sseldorf and R. R?hl from University of Potsdam. Currently, the main emphasis in this field is on the role of the antioxidant response element (ARE) and the transcription factor Nrf2 in the activation of phase II enzymes by carotenoids and their derivatives. In addition, we study the role of this transcription system in modulating the transcriptional activity of steroid receptors (estrogens, androgens and glucocorticoids). 2. The effect of carotenoids on bone derived cells and the modulation of hormonal activities in these cells. 3. Synergistic Anti-Leukemic Effects of Rosemary Antioxidants and Differentiation Inducers on Human Myeloid Leukemia Cells. The role of retinoid receptors, vitamin D and anti oxidative activities. Together with Michael Danilenko. This project is funded by BSF. 4 Clinical study: Bioavailability of carotenoid preparations in human volunteers with Y. Liel, Endocrinology Inst. 5. Clinical study: The effect of phytoestrogens and tomato carotenoids in post-menopausal women. With M. Halak, S. Lazer Division of Gynecology. 6. Clinical studies on the effect of tomato carotenoids on IGF-I blood levels: a) in colon cancer patients with S. Walfisch, colorectal unit, b) in prostate cancer patients with M. Baykara, Akdeniz University Faculty of Medicine, Antalya, Turkey. c) In postmenopausal women with M. Halak, S. Lazer, Division of Gynecology.