Prof. Sofia Schreiber-Avissar Profile

Prof. Sofia Schreiber-Avissar

Professor
PhD, 1983

Department :	Clinical Biochemistry and Pharmacology
Room :	525 בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם
Phone :	972-8-6477355
Email :	sofia@bgu.ac.il
Office Hours :

mood disorders, psychopharmacology, signal transduction

Education

Tel Aviv University 1971-1974 B.Sc degree, Department of Biology, The Hebrew University, Jerusalem, Israel 1977-1979 M.Sc. degree, Department of Biochemistry, Tel Aviv University, Tel Aviv, Israel. Thesis subject: "Regulation of Acetylcholine Release by Phosphorylation and by Presynaptic Receptors". Advisor: Prof. D. M. Michaelson. 1979-1983 Ph.D. degree, Department of Biochemistry, Tel Aviv University, Tel Aviv, Israel. Thesis subject: "Biochemical Characterization of Muscarinic Receptors in Rat Hypophysis and Hypothalamus and their Role in the Neuroendocrine System". Advisor: Prof. M. Sokolovsky.

Research Interests

psychopharmacology neurobiochemistry The involvement of GPCR signal transduction elements in the pathogenesis of affective disorders.
Molecular mechanisms underlying the pathogenesis of neuropsychiatric disorders; Pharmacological and biochemical aspects concerning the mechanism of action of drugs used in the treatment of neuropsychiatric disorders Neurochemical-psychopharmacological research focused on molecular mechanisms underlying the pathogenesis of major psychiatric disorders, and the mechanism of action of drugs used in the treatment of these disorders, with special emphasis on the importance of perturbations in signal transduction beyond receptors, involving guanine nucleotide binding proteins (G proteins) and their regulators.

Research Topics

Involvement of regulators of receptor desensitization in mood disorders and in the mechanism of action of antidepressant and antibipolar drugs
Differential role of beta-arrestin 1&2 in the pathophysiology of mood disorders.

Major expertise and techniques in the lab

Publications and funding summary / representative publications and grants

Golan, M., Schreiber, G., Avissar, S.: Antidepressants increase ?-arrestin2 ubiquitinylation and degradation by the proteasomal pathway in C6 rat glioma cells.
J Pharmacol Exp Ther. 332:970–976, 2010.
Golan, M., Schreiber, G., Avissar, S.: Antidepressants elevate GDNF expression and release from C6 glioma cells in a b-arrestin1-dependent, CREB interactive pathway. Int J Neuropsychopharmacol. 14:1289-1300, 2011.
Golan, M., Schreiber, G., Avissar, S.: Antidepressant-induced differential ubiquitination of ?-arrestins 1 and 2 in mononuclear leucocytes of patients with depression. Int J Neuropsychopharmacol. 16:1745-54, 2013.
Todder, D., Avissar, S., Schreiber, G.: Non-linear dynamic analysis of inter-word time intervals un psychotic speech. J. Transl. Eng. Health & Medicine. Vol.1 article # 2200107, 2013 DOI:10.1109/JTEHM.2013.2268850

Suggested multi-disciplinary research project / research focus topics