Prof. Shimon Ben-Shabat

Prof. Shimon Ben-Shabat Profile

PhD, 1999

Department : Clinical Biochemistry and Pharmacology
School of Pharmacy
Room : 541
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם
Phone : 972-8-6477363
Email :
Office Hours :  
Bioorganic and Medicinal Chemistry; Natural Products, cancer


  • 1999 – 2001 Postdoctoral Research Fellow, Department of Chemistry, Columbia University in the City of New York. (Mentor: Professor Koji Nakanishi).
  • 1999 Ph.D., Medicinal Chemistry, School of Pharmacy, Hebrew University of Jerusalem, Israel. (Advisor: Professor Raphael Mechoulam). Thesis: Isolation, identification, characterization and synthesis of endocannabinoids.
  • 1993 M.Sc., Medicinal Chemistry, School of Pharmacy, Hebrew University of Jerusalem, Israel. (Advisor: Professor Raphael Mechoulam).
  • 1991 B.Sc., Chemistry, Faculty of Natural Sciences, Hebrew University of Jerusalem, Israel.

Research Interests

  • Bioorganic studies of natural products: isolation, structural and mechanistic studies of endogenous compounds.
  • Medicinal Chemistry – structure activity relationship (SAR). Drug design - delivery and targeting (Prodrugs)
  • Isolation, structural characterization and synthesis of biomedically important bioactive compounds from plants sources for drug discovery purpose.


Research Topics

  • Bio-organic and Medicinal Chemistry.
  • Natural Products.

Major expertise and techniques in the lab

  • Bio-analytical studies (LC-MS, GC-MS)
  • Pro-drugs: design, synthesis and evaluation.
  • Structure Activity Relationship.

Publications and funding summary / representative publications and grants

  • Milica Markovic, Arik Dahan, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M Zimmermann, Shimon Ben-Shabat. 2019, Phospholipid-based prodrugs for colon targeted drug delivery: Experimental study and in-silico simulations. Pharmaceutics. 16;11(4).
  • Arik Dahan, Milica Markovic, Aaron Aponick, Ellen M. Zimmermann, Shimon    Ben- Shabat. 2019. The   Prospects of Lipidic Prodrugs: Old Approach with Emerging  Future. Future Medicinal Chemistry. 11(19):2563-2571.
  • Milica Markovic, Shimon Ben-Shabat, Aaron Aponick, Ellen M Zimmermann, Arik Dahan. Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics. International Journal of Molecular Sciences. Received, in press, 2020.
  • Ludmila Yarmolinsky, Arie Budovsky, Leonid Yarmolinsky, Boris Khalfin Vladimir Glukhman and Shimon Ben-Shabat. 2019. Effect of Bioactive Phytochemicals from Phlomis viscosa Poiret on Wound Healing. Plants (Basel). 16; 8(12).
  • Shimon Ben-Shabat, Ludmila Yarmolinsky, Daniel PoratS, and Arik Dahan. 2019. Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug Delivery and Translational Research. 10(2):354-367.
  • Dahan A, Markovic M, Keinan S, Kurnikov I, Aponick A, Zimmermann EM and Ben-Shabat S. 2017. Computational modeling and in-vitro/in-silico correlation of phospholipid-based prodrugs for targeted drug delivery in inflammatory bowel disease. J Comput Aided Mol Des. 31(11):1021-1028.
  • Dahan A, Markovic M, Epstein S, Cohen N, Zimmermann EM, Aponick A and Ben-Shabat S. 2017. Phospholipid-drug conjugates as a novel oral drug targeting approach for the treatment of inflammatory bowel disease. Eur J Pharm Sci. 108:78-85.
  • Agbaria R, Jubran A, Dahan A and Ben-Shabat S. 2015. Anticancer Activity of Nigella Sativa (Black Seeds) and its Relationship with the Seeds Thermal Processing and Quinone Composition. Drug Des Devel Ther. Jun 18;9:3119-24.


Existing collaborations

  • Amnon Sintov (BGU) - Prodrugs for dermal delivery and topical therapeutics.
  • Raphael Mechoulam (HU) – The role of cannabinoids and endocannabinoids in prevention of AMD .
  • Arik Dahan (BGU) - Drug targeting strategy for the treatment of inflammatory bowel disease (Novel Prodrugs) 


Suggested multi-disciplinary research project / research focus topics

  • Neurodegenerative diseases. Natural Products in Cancer Therapy.