Associate Professor
PhD, 1977
pharmacology, anti inflammation, proteins |
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- Hebrew University, Ph.D.1977
- Disfunctions related to endothelial cells (as hypertension).
- Cellular transduction, prostaglandins and cell signaling, pharmacology 1. olecular coupling between prostaglandins and membrane ion channels. 2. The molecular mechanism involved in prostaglandins overproduction in cells transfected with viral kinase gene (Herpes Simplex Thymidine kinase). 3. Interaction of specific cyclooxygenase-2 (COX-2) inhibitors with COX-1, molecular mechanism and implications
- Interaction of Nonsteroidal anti inflammatory drugs (NSAIDs) with cylooxygenase-1 and cylooxygenase-Interaction of cyclooxygenase with cellular transduction proteins.
Major expertise and techniques in the lab
- RIA measurements of Cyclooxygenase activity in cell culture.
Publications and funding summary / representative publications and grants
- Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation. Haddad A, Flint-Ashtamker G, Minzel W, Sood R, Rimon G, Barki- Harrington L. J Biol Chem. 2012, 287(21):17214-23.
- Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1. Rimon G, Sidhu RS, Lauver DA, Lee JY, Sharma NP, Yuan C, Frieler RA, Trievel RC, Lucchesi BR, Smith WL. Proc Natl Acad Sci U S A. 2010;107(1):28-33.
- Barki-Harrington L. Source Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Mt. Carmel, Haifa 31905, Israel. - Interaction of cellular signaling proteins with cyclooxygenase.
- Smith WL. Department of Biological Chemistry, University of Michigan , Ann Arbor , MI 4810, USA . – Interaction of NSAIDs with cyclooxygenase.
Suggested multi-disciplinary research project / research focus topics
- Identification of cellular proteins that interact with cyclooxygenase enzyme and affect its activity or degradation.