Dr. Vladimir Gavrilov
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Researcher C
Department :
Clinical Biochemistry and Pharmacology
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Email :
gavrilov@bgu.ac.il
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Education
M.D. 1967 – 1973: Tajik State Medical Institute Ph.D. 1983-1988: Institute of Obstetrics and Gynecology, the USSR Academy of Medical Sciences, Leningrad Thesis title: Endocrine function of feto-placental complex during anemia.
Research Interests
"Prostate Cancer treatment" is the main issue I am working on. The approaches our group elaborate are: a) The use of less calcemic synthetic analogs of vitamin D, 1,24(S)(OH)2D2 and JK-1624-3), b) The combined use of the active metabolite of vitamin D, 1,25(OH)2D3, with non-steroidal anti-inflammatory drug ibuprofen and with histone deacetylase inhibitors, c) combination of 1,25(OH)2D3, histone deacetylase inhibitors and ionizing radiation in treatment of prostate cancer cells. "Vitamin A excretion in patients with kidney proximal tubule injury" is another issue of my research interests.
Research Projects
Intracellular signaling pathways responsible for the sensitization to ionizing radiation of prostate cancer cells pretreated with a combination of 1,25(OH)2D3 and sodium valproate
Research Topics
Combinations of the istone deacetlase inhibitor valproic acid wit chemoradioterapy for enhanced treatment and lung and pancreaic cancer
Enhanced anticancer treatment with the combination of vitamin D agents with the inhibitor of vitamin D catabolism ketoconazole and with the histone deacetylase inhibotor alproic acid
Existing collaborations
Prof. Samuel Ariad and Dr. Konstantin Lavrenkov, Dept. of Oncology, Soroka Medical Center - combination of the histone deacetylase inhibitor valproic acid with chemoradiotheraphy for enhanced anticancer therapy
Prof. Shraga Shany - enhanced anticancer treatment using combinatiion of vitamin D agents with histone deacetylase in inhibitors and inhibitors of vitamin D agents catabolisms