Prof. Vadim Fraifeld

Prof. Vadim Fraifeld Profile

Researcher A
M.D., Ph.D.


Department : Shraga Segal Department of Microbiology, Immunology and Genetics
Room : 235
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם
Phone : 972-8-6477292
Email :
Office Hours :  
Biology of Aging and Longevity, Systems Biology of Aging, Mitochondria, Wound Healing, Fibrosis, Cellular Senescence, Experimental Life Span Extension


  •  MD, PhD

Research Interests

  • Determinants of aging, longevity and age-related diseases
  • Comparative analysis of mitochondrial genome
  • Wound healing, Fibrosis, Cellular Senescence
  • Microbiota and aging

Research Projects

  • Searching for determinants of aging, longevity, and late-onset diseases
  • Wound Healing and Pulmonary Fibrosis
  • Cellular Senescence
  • Construction of Longevity-related Databases
  • Microbiota and aging

Major expertise and techniques in the lab

  • Systems Biology of Aging
  • Molecular and cellular biology
  • Primary and cell line cultures
  • In vivo experiments

Publications and funding summary / representative publications and grants

  • Yanai H, Budovsky A, Barzilay T, Tacutu R, Fraifeld VE. Wide-scale comparative analysis of longevity genes and interventions. Aging Cell 2017 Aug 24. doi:10.1111/acel.12659.
  • Gobshtis N, Tfilin M, Wolfson M, Fraifeld VE, Turgeman G. Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid. Oncotarget 2017; 8:17443-17452.
  • Yehuda S, Yanai H, Priel E, Fraifeld VE. Differential decrease in soluble and DNA-bound telomerase in senescent human fibroblasts. Biogerontology 2017. doi: 10.1007/s10522-017-9688-6. [Epub ahead of print]
  • Yanai H, Budovsky A, Tacutu R, Barzilay T, Abramovich A, Ziesche R, Fraifeld VE. Tissue repair genes: the TiRe database and its implication for skin wound healing. Oncotarget 2016;7:21145-55.
  • Toren D, Barzilay T, Tacutu R, Lehmann G, Muradian KK, Fraifeld VE. MitoAge: a database for comparative analysis of mitochondrial DNA, with a special focus on animal longevity. Nucleic Acids Res 2016;44(D1):D1262-5.
  • Yanai H, Shteinberg A, Porat Z, Budovsky A, Braiman A, Zeische R, Fraifeld VE. Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients. Aging (Albany NY) 2015;7:664-72.
  • Calio A, Zamo A, Ponzoni M, Zanolin ME, Ferreri AJ, Pedron S, Montagna L, Parolini C, Fraifeld VE, Wolfson M, Yanai H, Pizzolo G, Doglioni C, Vinante F, Chilosi M. Cellular Senescence Markers p16INK4a and p21CIP1/WAF Are Predictors of Hodgkin Lymphoma Outcome. Clin Cancer Res. 2015;21:5164-72.
  • Yanai H, Toren D, Vierlinger K, Hofner M, Nohammer C, Chilosi M, Budovsky A, Fraifeld VE. Wound healing and longevity: lessons from long-lived alpha-MUPA mice. Aging (Albany NY) 2015;7:167-76.
  • Lehmann G, Muradian KK, Fraifeld VE. Telomere length and body temperature -- independent determinants of mammalian longevity? Front Genet 2013;4:111.
  • Moskalev AA, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Yanai H, Fraifeld VE. The role of DNA damage and repair in aging through the prism of Koch-like criteria. Ageing Res Rev. 2013 Mar;12(2):661-84.
  • Tacutu R, Budovsky A, Yanai H, Fraifeld VE. Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective. Aging (Albany NY) 2011;3:1178-91.
  • Tacutu R, Shore DE, Budovsky A, de Magalhaes JP, Ruvkun G, Fraifeld VE, Curran SP. Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One 2012;7(10):e48282.
  • Wolfson M, Budovsky A, Tacutu R, Fraifeld V. The signaling hubs at the crossroad of longevity and age-related disease networks. Int J Biochem Cell Biol 2009;41:516-20.

Existing collaborations

  • Prof. Rolf Ziesche
    CEO "Transgenion"
    Vienna, Austria
  • Prof. Khachik Muradian
    Institute of Gerontology
    Kiev, Ukraine
  • Dr. Joao Pedro de Magalhaes
    Institute of Ageing and Chronic Disease
    University of Liverpool, UK
  • Prof. Marco Chilosi
    University of Verona, Italy
  • Dr. Yelena Budovskaya
    Stanford University, USA

Additional links