Senior lecturer
MD: 1988 Ph.D. 1999
- Ph.D. 1991- 1999 – Ben-Gurion University of the Negev, Beer-Sheva Thesis : Signal transduction transgression and transcriptional derangements In metastatic and non-metastatic tumor cell variants Summa cum laude Supervisor: Prof. S. Segal M.D. 1982 – 1988 – State Institute of Medicine, Chelyabinsk, USSR
- Melanoma cell biology and physiology
- Lipid rafts and tumor-promoting Ca 2+ -signaling in malignant cells
Major expertise and techniques in the lab
- Signal transduction and Ca2+-signaling
- Confocal microscopy
- Flow cytometry
Publications and funding summary / representative publications and grants
- Fedida-Metula S, Feldman B, Koshelev V, Levin-Gromiko U, Voronov E, Fishman D (2012) Lipid rafts couple store-operated Ca2+-entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway, and promote melanoma tumor growth. Carcinogenesis . doi: 10.1093/carcin/bgs021 P2.
- Feldman B, Fedida-Metula S, Nita J, Sekler I, Fishman D (2010) Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells. Cell Calcium .47(6):525-37 P3.
- Fedida-Metula S, Elhyany S, Tsory S, Segal S, Hershfinkel M, Sekler I, Fishman D. Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells. Carcinogenesis . 2008 Aug;29(8):1546-54. F1.
- 2010 – 2012 Israeli Ministry of Health grant on “The potential application of agents targeting cellular cholesterol and calcium-driven oncogenic signaling in melanoma therapy".
- 2008 – 2012 Israel Science Foundation grant “A novel approach to eradicate melanoma: targeting membrane micro-domains by cholesterol depletion inhibits PKB by disrupting calcium homeostasis and restrains tumor growth”.
- Michael Danilenko – targeting AML via disruption of Ca2+ homeostasis
Suggested multi-disciplinary research project / research focus topics