Prof. Sigal Fleisher-Berkovich

Prof. Sigal Fleisher-Berkovich Profile

Associate Professor
PhD., 1999

Department : Clinical Biochemistry and Pharmacology
School of Pharmacy
Room : 531
בנין מעבדות מחקר רפואה ע"ש דייכמן - פלאם - M6
Phone : 972-8-6477377
Email :
Office Hours :  
pharmacology, immunology, brain, neuro degeneration, inflammation


  • Ben-Gurion University of the Negev, Michigan State University

Research Interests

  • Neuroendocrine-Immune interaction,
  • Inflammation,
  • Pharmacology

Research Topics

  • My research focuses on the mechanisms by which inflammation is modulated, its effects on neuroglia and the manner in which this impacts on neurodegenerative diseases. The research is unique in showing that neuropeptides, powerful regulators of peripheral inflammation, also exert important effect on inflammation in the brain. This raises the possibility of new therapeutic strategies for treatment of neurodegenerative disease featuring anti-inflammatory neuropeptide receptor agonists or antagonists

Major expertise and techniques in the lab

  • Primary glial cultures inflammatory mediators’ analysis Immunohistochemistry

Publications and funding summary / representative publications and grants

  • Filipovich-Rimon T., Fleisher- Berkovich S. 2010, Glial response to lipopolysaccharide: possible role of endothelins . Peptides, 31:2269-75. Fleisher- Berkovich S. , Filipovich-Rimon T., Ben-Shmuel S, H?lsmann C, Kummer MP, Heneka MT. 2010, Distinct modulation of microglial amyloid beta phagocytosis and migration by neuropeptides. Journal of Neuroinflammation , 7:61-66. Grants 2007-2010, ISF, Fleisher- Berkovich Sigal (PI.1), Danon Abraham (PI. 2), Avissar Sofia (CI.1), Brain inflammation: what role does bradykinin play? 2011-13, ISF, Fleisher- Berkovich Sigal , Modulation of glial function by kinins : possible implications for brain inflammation.

Suggested multi-disciplinary research project / research focus topics

  • Neurobiology