Senior lecturer
PhD, 2006
B.Sc committee - chairman
protein, pharmacology, protein engineering, cancer, imaging |
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- B.Sc. , 1997, Hebrew University of Jerusalem. Israel., Chemistry
- M.Sc. , 2000, Hebrew University of Jerusalem. Israel., Pharmacokinetics
- Ph.D. , 2006, Weizmann Institute of Science. Rehovot. Israel., Biological chemistry
- Protein Engineering, directed evolution, ligand-receptor interactions, angiogenesis, cancer therapy, wound healing, in vivo imaging
- Rational and Combinatorial Engineering of Antagonistic Angiopoietin Variants as Tools for Cancer Imaging
- Developing bi-specific APPI peptides and small molecule conjugates that bind to both ?v?3 integrin and
MT1-MMP for clinical translation as diagnostic agents
- Developing dual-specific proteins that target multiple receptors involved in angiogenesis for cancer imaging and therapy
Major expertise and techniques in the lab
- Protein engineering
- Directed evolution
- In vivo imaging
Publications and funding summary / representative publications and grants
- Papo, N. , Silverman, A.P., Lahti, J.L., and Cochran, J.R. (2011) “Antagonistic VEGF Variants Engineered to Simultaneously Bind to and Inhibit VEGFR2 and ? v ? 3 Integrin”. Proc. Natl. Acad. Sci. U.S.A. 108, 14067-14072 .
- Papo, N. , Seger , D., Makovitzki , A., Kalchenko , V., Eshhar , Z., Degani , H., and Shai,Y . (2006) “Inhibition of Tumor Growth and Elimination of Multiple Metastases in Human Prostate and Breast Xenografts by Systemic Inoculation of a Host-Defense-Like Lytic Peptide.” Cancer Res. 66, 5371-5378 . - Marie curie career integration grants (ANGIOPOIETINS) funded by the European Commission ( people programme , FP7), 100,000 €. Rational and Combinatorial Engineering of Antagonistic Angiopoietin Variants as Tools for Cancer Imaging and Therapy. - Concern Foundation , Conquer Cancer Now Award, $120,000, two years. Developing Antagonistic Protein Ligands for Cancer Imaging and Therapy .
- Irit Sagi: Developing bi-specific APPI peptides and small molecule conjugates that bind to both ?v?3 integrin and MT1-MMP for clinical translation as diagnostic agents
- Eyal Mishani : Developing dual-specific proteins that target multiple receptors involved in angiogenesis for cancer imaging and therapy
Suggested multi-disciplinary research project / research focus topics
- Drug design
- Protein recognition
Looking for expertise / project
- In vivo molecular imaging