Dr. Gad Vatine Profile

Dr. Gad Vatine

Senior lecturer

Department :	Physiology and Cell Biology
Room :	323 בניין להנדסת ביוטכנולוגיה, ע"ש משפחת גוזיק - 42
Phone :	972-74-7795228 972-74-7795229
Email :	vatineg@bgu.ac.il
Office Hours :

stem-cell

Education

Postdoctoral: The Regenerative Medicine Institute, Cedars-Sinai medical Center, Los Angeles, CA
Ph.D: Department of Neurobiology, The Faculty of life science, Tel Aviv University

Research Interests

Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g. brain endothelial cells, pericytes, astrocytes and neurons.
Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).

Research Abstract

Our research aims to understand the mechanisms that underlie neurological disorders and develop personalized therapeutic approaches for patients. We use patient-specific stem cells to recreate diseases in a dish. Our main interest is to study the role of the blood brain barrier (BBB) in neurological disorders.

Research Topics

Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g.brain endothelial cells, pericytes, astrocytes and neurons.-----
Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).

Major expertise and techniques in the lab

Publications and funding summary / representative publications and grants

Vatine GD, Al-Ahmad A, Barriga BK, Svendsen S, Salim A, Garcia L, Chen Z, Van Eyk J, Palecek SP, Refetoff S, Shusta EV, Svendsen CN (2017). Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier. Cell Stem Cell. 1934-5909(17)30126-1.
Sances S, Ho R, Vatine GD, West D, Laperle A, Meyer A, Godoy M, Kay PS, Mandefro B, Hatada S, Hinojsa C, Wen N, Sareen D, Hamilton GA, Svendsen CN. (2018). Brain microvascular endothelial cells and microengineered Chip environment accelerate neuronal maturation in vitro. Cell Rep. In press.
Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D and Thompson LM (2017). Blood-brain barrier and angiogenic deficits in Huntington's disease iPSC-derived brain microvascular endothelial cells revealed through transcriptome and functional analysis. Cell Rep. 19(7):1365-1377.
Canfield S, Stebbins M, Morales B, Asai S, Vatine GD, Svendsen CN, Palecek SP, Shusta EV (2016). An Isogenic Blood-Brain Barrier Comprising Brain Endothelial Cells, Astrocytes and Neurons Derived from Human Induced Pluripotent Stem Cells. J Neurochem. 140(6):874-888.

Existing collaborations

Suggested multi-disciplinary research project / research focus topics

Looking for expertise / project