Associate Professor
Ph.D 1990
- Ph.D., Faculty of Health Sciences, Department of Clinical Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Thesis advisor: Prof. Z. Ben-Zvi. Thesis: "The effects of clonidine, an ?-2-adrenoreceptor agonist, on the biliary excretion of drugs
- 1980 - 1983 B.Sc., Faculty of Natural Sciences, Department of Biology, Ben-Gurion University of the Negev, Beer-Sheva, Israel. 1983 - 1986
- M.Sc., Faculty of Natural Sciences, Departments of Biology and Clinical Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Thesis advisor: Prof. Z. Ben-Zvi and Prof. U. Sod-Moriah. Thesis: “The involvement of glutathione and glutathione-S-transferase in the toxicity of dibromochloropropane". 1986-1991 Ph.D., Faculty of Health Sciences, Department of Clinical Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Thesis advisor: Prof. Z. Ben-Zvi. Thesis: "The effects of clonidine, an ?-2-adrenoreceptor agonist, on the biliary excretion of drugs."
- Postdoctoral Training: 1991 - 1994 Postdoctoral Fellow, Laboratory of Medicinal Chemistry, Developmental Therapeutics Program, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA. Conducted research in the areas of molecular and cellular biochemical pharmacology and biochemistry of prodrugs used in genetically modified (transfected) tumor cells. Analytical biochemistry, the biochemical pharmacology, and clinical pharmacology of new antitumor and antiviral (anti-AIDS) agents. Under the direction of Dr. David G. Johns and Dr. James A. Kelley.
- Molecular and cellular biochemical pharmacology of prodrugs used in genetically modified (transfected) tumor cells. Molecular and cellular biochemical pharmacology of antitumor and antiviral agents (anti-AIDS and HSV).
- Gene therapy of cancer and HIV. Molecular and cellular biochemical pharmacology of prodrugs used in genetically modified (transfected) tumor cells. Molecular and cellular biochemical pharmacology of antitumor and antiviral agents (anti-AIDS and HSV).
- Gene therapy of cancer and HIV.
- Metabolic activation of prodrugs under development.
- Pharmacokinetics and metabolism of anticancer and antiviral drugs
Major expertise and techniques in the lab
- Animal and tissue culture techniques
- Analytical and molecular tests
Publications and funding summary / representative publications and grants
- Dahan A, Beig A, Ioffe-Dahan V, Agbaria R, Miller JM: The Twofold Advantage of the Amorphous Form as an Oral Drug Delivery Practice for Lipophilic Compounds: Increased Apparent Solubility and Drug Flux Through the Intestinal Membrane. AAPS J. 2012 Dec 15. [Epub ahead of print]
- Dahan A, Khamis M, Agbaria R, Karaman R: Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach. Expert Opin Drug Deliv. 9:1001-13, 2012.