Senior lecturer
PhD, 1995
Pharmacology, Gonado tropins, Protein, Drosophila, Biochemistry |
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- B.Sc.- The Hebrew University of Jerusalem, Faculty of Agriculture, Rehovot, Israel
- M.Sc.- The Weizmann Institute of Science, Department of Cell Biology, Rehovot, Israel Thesis advisor: Prof. A. Globerson; Title of thesis: “Developmental aspects of T Lymphocytes in aging"
- Practical Engineering (Handessai degree")-The Open University of Israel, School of Technology (Electronics), Tel-Aviv, Israel Project Advisor: Dr. G. Golan Title of project: “Electrical properties of the hair”
- Ph.D.- Tel Aviv University, Department of Biochemistry, Tel-Aviv, Israel Thesis advisor: Prof. Z. Naor; Title of thesis: “Regulation of gonadotropin biosynthesis by GnRH and paracrine factors"
- Mechanism of gonadotropin receptor activation;
- Design of recombinant bovine gonadotropin for potential application in animal agriculture;
- Using Drosophila melanogaster as a model to study potential geroprotective compounds.
- Molecular and biochemical pharmacology of the gonadotropins and their receptors.
- Post-translational modifications of recombinant proteins.
- Human and animal reproduction
- Gonadotropins and their receptors
- Protein Engineering
- Signal transduction
- Drosophila
Major expertise and techniques in the lab
- Molecular biology
- Drosophila related techniques
- Biochemical analysis of proteins
Publications and funding summary / representative publications and grants
- Nurwakagari P., Breit A., Hess C., Salman-Livny H., Ben-Menahem D. and Gudermann T. A Conformational Contribution of the Luteinizing Hormone Receptor Ectodomain to Receptor Activation. J. Mol. Endocrinol. 38: 259-275, 2007.
- Grinberg M, Nakav S., Pen S., Dantes A., Braw-Tal R., Amsterdam A., and Ben-Menahem D. The configuration of the alpha and beta subunit domains in single-chain bovine LH analogs influences the secretion and steroidogenic response. Mol. Cell. Endocrinol. 283: 83-95, 2008.
- Smeltzer Z., Karter M., Eisenstein M., Leto TL., Hadad N., Ben-Menahem D., Gitler D., Banani S., Wolach B., Rotem M., Levy R. Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain. J Biol Chem. 283:31898-31908, 2008.
- Dr. Ross L. Cagan
- Dr. Eitan Rubin
Suggested multi-disciplinary research project / research focus topics
- Gonadotropins bioinformatics
- Potential extra gonadotropic activities of the gonadotropins (e.g., cancer, bone metabolism)