Prof. Nurit Porat

Prof. Nurit Porat Profile


Department : Infectious Diseases
Shraga Segal Department of Microbiology, Immunology and Genetics
School of Pharmacy
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infectious diseases, micro biology, immunology, pneumonia, bacteria, bio chemistry

Research Interests

Research Topics

  • Molecular epidemiology of S. pneumoniae before and after the introduction of the 7-valent pneumococcal conjugate vaccine
  • How do S. pneumoniae cope with oxidative burst?
  • H 2 O 2 signaling in S. pneumoniae
  • Distinction of S. pneumoniae serotypes by using FTIR spectroscopy

Major expertise and techniques in the lab

  • Molecular typing of bacteria
  • Bacterial pathogenesis
  • Enzyme biochemistry
  • Redox modifications of cysteine residues
  • Membrane biophysical characterization

Publications and funding summary / representative publications and grants

  • Pesakhov S, Benisty R, Sikron N, Cohen Z, Khozin-Goldberg I, Gomelski P, Dagan R, Porat N . Effect of hydrogen peroxide production and the Fenton reaction on membrane composition of Streptococcus pneumoniae . Biochim. Biophys. Acta – Biomembranes 1768:590-7. 2007. 2. Dagan R, Givon-Lavi N, Leibovitz E, Greenberg D, Porat N . Introduction and proliferation of multidrug-resistant Streptococcus pneumoniae serotype 19A clones that cause acute otitis media in an unvaccinated population. J Infect Dis 199:776-85. 2009. 3. Porat N , Amit U, Givon-Lavi N, Leibovitz E, Dagan R. Increasing Importance of Multidrug Resistant Serotype 6A S. pneumoniae Clones in Acute Otitis Media in Southern Israel . Pediatr Infect Dis J 29:129-130. 2010. 4. Benisty R, Cohen AY, Feldman A, Cohen Z, Porat N . Endogenous H 2 O 2 produced by Streptococcus pneumoniae control FabF activity. Biochim. Biophys. Acta - Mol Cell Biol Lipids; 1801:1098-104. 2010.

Existing collaborations

  • Ron Dagan & David Greenberg : Molecular epidemiology of S. pneumoniae pre- and post-vaccine
  • Yaffa Mizrachi Nebenzahl: S. pneumoanie physiology
  • Zvi Cohen: Bacterial membrane adaptation to stress conditions
  • Itzhak Fishov : Biophysical characterization of bacterial membrane