Selected Publications

  1. CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis.  Zaccai S et al., J Neuroinflammation. 2024 Jan 11;21(1):17. 
  2. Brain-immune axis regulation is responsive to cognitive behavioral therapy and mindfulness intervention: Observations from a randomized controlled trial in patients with Crohn’s disease.  Nemirovsky A. et al., Brain Behav Immun Health. 2021 Dec 23;19:100407. 
  3. Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair.  Elyahu Y, Monsonego A. Ageing Res Rev. 2021 Jan;65:101231. Review. 
  4. Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.  Elyahu Y & Hekselman I et al., Sci Adv. 2019 Aug 21;5(8):eaaw8330. 
  5. CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology.  Mittal K et al., iScience. 2019 Jun 28;16:298-311. 
  6. BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer’s disease.  Eremenko E. et al., EBioMedicine. 2019 May;43:424-434. 
  7. The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System.  Strominger I. et al., Front Immunol. 2018 May 16;9:1066. 
  8. TGF-β affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation.  Orr S. et al., Acta Biomater. 2016 Nov;45:196-209. 
  9. Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer’s disease.  Baron R. et al., Aging Cell. 2014 Aug;13(4):584-95.  
  10. Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance.  Fisher Y. et al., J Immunol. 2014 Jan 1;192(1):92-102. 
  11. Chronic exposure to stress predisposes to higher autoimmune susceptibility in C57BL/6 mice: glucocorticoids as a double-edged sword.  Harpaz I  et al., Eur J Immunol. 2013 Mar;43(3):758-69. 
  12. TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment.  Abutbul S et al., Glia. 2012 Jul;60(7):1160-71. 
  13. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.  Zota V et al., J Immunol. 2009 Sep 1;183(5):3522-30. 
  14. Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer’s disease.  Monsonego A et al., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5048-53. 
  15. Immunotherapeutic approaches to Alzheimer’s disease.  Monsonego A, Weiner HL. Science. 2003 Oct 31;302(5646):834-8. Review. 
  16. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.  Monsonego A et al., J Clin Invest. 2003 Aug;112(3):415-22. 
  17. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer’s disease.  Monsonego A et al., Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10273-8