Itay Rousso's Lab

Nanomechanics of biological complexes

Our research focuses on the interrelations between three modules of large biological assemblies: structure, material properties and function. Currently our laboratory is engaged with the investigation of the physical properties underlying retrovirus replication, and the role of the mammalian tectorial membrane in hearing micromechanics. In addition, we have developed a time-resolved atomic force microscope with unparalleled combination of lateral and temporal resolutions.

This novel microscope allows us to study, for the first time, the dynamic properties of the mammalian tectorial membrane during physiological relevant motion. In our research we use standard molecular and cellular biology methods in combination with advanced biophysical methods including atomic force microscopy (AFM), fluorescence and electron microscopy, as well as techniques such as two-photon second harmonic microscopy, and mainly force spectroscopy.